Apolipoprotein E elicits isoform-dependent effects on macrophage cytokine secretion.

Tsoi Lo Ming. ; Thesis (M.Phil.)--Chinese University of Hong Kong, 2006. ; Includes bibliographical references (leaves 99-109). ; Abstracts in English and Chinese. ; Acknowledgements --- p.I ; Abstract --- p.II ; Abstract in Chinese --- p.III ; List of Abbreviations --- p.IV ; List of Figures --- p.V ; List of Tables --- p.VI ; Table of Contents --- p.VII ; Chapter Chapter 1 : --- Introduction ; Chapter 1.1. --- Apolipoprotein and Lipoprotein Metabolism --- p.1 ; Chapter 1.2. --- Molecular Information of ApoE --- p.2 ; Chapter 1.3. --- Tissue Distribution of ApoE --- p.2 ; Chapter 1.4. --- Functions of ApoE --- p.4 ; Chapter 1.5. --- Genetic Polymorphism of ApoE --- p.7 ; Chapter 1.6. --- Protein Structure and Characteristics of ApoE Isoforms --- p.9 ; Chapter 1.7. --- Plasma and Cellular Expression Level of ApoE Isoforms --- p.12 ; Chapter 1.8. --- Association between ApoE Isoforms and Plasma Lipid Profiles --- p.13 ; Chapter 1.9. --- ApoE Polymorphisms and Pathophysiological Conditions ; Chapter 1.9.1. --- Type III Hyperlipoproteinemia (Type III HLP) --- p.14 ; Chapter 1.9.2. --- Alzheimer's Disease --- p.15 ; Chapter 1.9.3. --- Atherosclerosis ; Chapter 1.9.3.1. --- Atherosclerosis - An Inflammatory Process --- p.15 ; Chapter 1.9.3.2. --- Role of ApoE in Atherosclerosis --- p.18 ; Chapter (a) --- Functions Associated to Lipid Metabolism --- p.19 ; Chapter (b) --- Functions Independent to Lipid Metabolism --- p.20 ; Chapter 1.9.3.3. --- TNF-α and IL-6 in Atherosclerosis --- p.25 ; Chapter 1.10. --- Macrophage Cytokine Expression and MAPKs ; Chapter 1.10.1. --- Organization of MAPKs Signaling Pathway --- p.26 ; Chapter 1.10.2. --- Lipopolysaccharide and MAPKs in Macrophage Cytokine Expression --- p.28 ; Chapter 1.10.3. --- Regulation of Macrophage Cytokine Expression ; Chapter 1.10.3.1. --- ERK1/2 and p38 MAPK Pathway --- p.30 ; Chapter 1.10.3.2. --- Arachidonic Acid Metabolism --- p.30 ; Chapter 1.11. --- Aim and Hypothesis --- p.31 ; Chapter Chapter 2 : --- Materials and Methods ; Materials ; Chapter 2.1 --- ...