The regulatory expression pattern of monocytes in metabolic disorders and sepsis patients

In current study, we demonstrated a special and distinct modulation pattern of monocytes in sepsis patients with different metabolic disturbance. As a novel finding, we identified the selective diminution of CD14+ (Classical monocytes) and CD33 expression in monocytes in sepsis. This effect is more pronounced in patients with diabetes during progression of sepsis and septic shock. Obese diabetic patients have higher non-classical monocyte counts in non-sepsis and increase CD16 expression as well as CD163 under septic conditions.