Dopamine transporter changes after unilateral deep brain stimulation in progressive Parkinson's disease: a case report

Huiwei Zhang,1,* Yuanyuan Wang,1,* Jinchuan Liang,2 Stefan Förster,3 Ping Wu,1 Jun Zhao,1 Yihui Guan,1 Chuantao Zuo1 1PET Center, Huashan Hospital, Fudan University, 2Department of Neurosurgery, Changhai Hospital, Shanghai, People's Republic of China; 3Department of Nuclear Medicine and TUM-Neuroimaging Center, Technical University Munich, Munich, Germany *These authors contributed equally to this work Abstract: Deep brain stimulation (DBS) at the subthalamic nucleus has been approved as an effective treatment for refractory symptoms of Parkinson's disease (PD). Studies have shown that bilateral DBS surgery in PD patients results in clinical improvement without reducing dopamine transporter function. Here, we report our longitudinal findings in one PD patient, ie, decreases in striatal dopamine transporter binding during one year of follow-up after unilateral DBS at the subthalamic nucleus. Based on this case, we hypothesize that clinical benefit after unilateral DBS may be not directly associated with changes in function at the subthalamic nucleus. Keywords: deep brain stimulation, Parkinson's disease, dopamine transporter, positron emission tomography