نبذة مختصرة : Background: Preliminary data suggests that obesity might hasten the decline in mRNA vaccine-induced immunity against SARS-CoV-2. However, whether this renders individuals with obesity more susceptible to long COVID symptoms post-vaccination remains uncertain. Given sleep’s critical role in immunity, exploring the associations between obesity, probable long COVID symptoms, and sleep disturbances is essential. Methods: We analyzed data from a survey of 5919 adults aged 18 to 89, all of whom received two SARS-CoV-2 mRNA vaccinations. Participants were categorized into normal weight, overweight, and obesity groups based on ethnicity-specific BMI cutoffs. The probability of long COVID was evaluated using the Post-Acute Sequelae of SARS-CoV-2 (PASC) score, as our survey did not permit confirmation of acute SARS-CoV-2 infection through methods such as antibody testing. Additionally, sleep patterns were assessed through questionnaires. Results: Participants with obesity exhibited a significantly higher adjusted odds ratio (OR) of having a PASC score of 12 or higher, indicative of probable long COVID in our study, compared to those with normal weight (OR: 1.55, 95% CI: 1.05, 2.28). No significant difference was observed for overweight individuals (OR: 0.92 [95% CI: 0.63, 1.33]). Both obesity and probable long COVID were associated with increased odds of experiencing a heightened sleep burden, such as the presence of obstructive sleep apnea or insomnia (P < 0.001). However, no significant interaction between BMI and probable long COVID status was found. Conclusions: Even post-vaccination, individuals with obesity may encounter a heightened risk of experiencing prolonged COVID-19 symptoms. However, confirming our observations necessitates comprehensive studies incorporating rigorous COVID infection testing, such as antibody assays - unavailable in our anonymous survey. Additionally, it is noteworthy that the correlation between probable long COVID and sleep disturbances appears to be independent of BMI. ; Peer reviewed
Relation: CB receives financial support from the Novo Nordisk Foundation (NNF23OC0081873) and the Swedish Brain Research Foundation (FO2023-0292). P.X. research is financially supported by the \u00C5ke Wiberg Foundation (M23-0040) and Tore Nilsson Foundation (2023-079). IM and MP\u2019s research is financially supported by the Signe and Arne Gyllenberg Foundation (IM: #5815 and MP: #5961). The funding sources had no involvement in the design, implementation, data analysis, interpretation, or manuscript preparation of this study. Open access funding provided by Uppsala University.; Xue , P , Merikanto , I , Delale , E A , Bjelajac , A , Yordanova , J , Chan , R N Y , Korman , M , Mota-Rolim , S A , Landtblom , A M , Matsui , K , Reis , C , Penzel , T , Inoue , Y , Nadorff , M R , Holzinger , B , Morin , C M , Espie , C A , Plazzi , G , De Gennaro , L , Chung , F , Bjorvatn , B , Wing , Y K , Dauvilliers , Y , Partinen , M & Benedict , C 2024 , ' Associations between obesity, a composite risk score for probable long COVID, and sleep problems in SARS-CoV-2 vaccinated individuals ' , International Journal of Obesity . https://doi.org/10.1038/s41366-024-01556-w; ORCID: /0000-0002-8182-9368/work/162651387; ORCID: /0000-0002-1222-6678/work/162652557; http://hdl.handle.net/10138/577836; 5d830e91-940b-466d-a957-ab07e82fc365; 85195414064; 001243340900001
No Comments.