Contributors: Epidémiologie et Biostatistique Bordeaux; Université Bordeaux Segalen - Bordeaux 2-Institut National de la Santé et de la Recherche Médicale (INSERM); Equipe Epidémiologie et neuropsychologie du vieillissement cérébral; Université Bordeaux Segalen - Bordeaux 2-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Bordeaux Segalen - Bordeaux 2-Institut National de la Santé et de la Recherche Médicale (INSERM); Unité Mixte de Recherche Epidémiologique et de Surveillance Transport Travail Environnement (UMRESTTE UMR T9405); Université Claude Bernard Lyon 1 (UCBL); Université de Lyon-Université de Lyon-Institut Français des Sciences et Technologies des Transports, de l'Aménagement et des Réseaux (IFSTTAR); Service de l'évaluation, de la surveillance du risque et de l'information sur le médicament; AFSSAPS; Sommeil, Addiction et Neuropsychiatrie Bordeaux (SANPSY); Université de Bordeaux (UB)-CHU de Bordeaux Pellegrin Bordeaux -Centre National de la Recherche Scientifique (CNRS); Pharmacoepidemiologie et évaluation de l'impact des produits de santé sur les populations; Université Bordeaux Segalen - Bordeaux 2-Université de Rouen Normandie (UNIROUEN); Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM); CIC - Bordeaux; Université Bordeaux Segalen - Bordeaux 2-CHU Bordeaux-Institut National de la Santé et de la Recherche Médicale (INSERM); The CESIR-A project was funded by the Afssaps, the French National Research Agency (ANR, DAA n° 0766CO204), the French Medical Research Foundation (Equipe FRM), the French Direction Générale de la Santé (DGS) and the French National Medical Research Institute (Equipe INSERM).; CESIR research group; ANR-07-TSFA-0001,CESIR-A,Santé et insécurité routière : influence de la consommation de médicaments(2007)
نبذة مختصرة : Studies assessing the impact of epilepsy and its medication on the risk of road traffic crashes have shown inconsistent results. The aim in this study was to assess this risk using French databases. Data from three French national databases were extracted and matched: the national health care insurance database, police reports, and the national police database of injurious crashes. Only antiepileptics prescribed predominantly in epilepsy were studied (phenobarbital, phenytoin, ethosuximide, valproic acid, vigabatrin, tiagabin, levitiracetam, zonisamide, and lacosamide). A case-control analysis comparing responsible and non-responsible drivers and a case-crossover analysis were performed. Drivers (72 685) involved in an injurious crash in France between July 2005 and May 2008, were included. Drivers exposed to prescribed antiepileptic medicines (n = 251) had an increased risk of being responsible for a crash (OR 1.74 [1.29-2.34]). The association was also significant for the most severe epileptic patients (n = 99; OR = 2.20 [1.31-3.69]). Case-crossover analysis found no association between crash risk and treatment prescription. Patients with prescription of antiepileptic drugs should be cautioned about their potential risk of road traffic crash. This risk is however more likely to be related to seizures than to the effect of antiepileptic medicines.
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