ANTI-HYPERLIPIDEMIA ACTIVITY IN THE VIVO TEST FROM A COMBINATION OF AVOCADO LEAF EXTRACT (Persea americana Mill) AND GINGER RHIZOME (Curcuma xanthorrhiza Roxb) IN MICE WITH HYPERCHOLESTEROLEMIA: AKTIVITAS ANTI-HIPERLIPIDEMIA PADA UJI IN VIVO DARI KOMBINASI EKSTRAK DAUN ALPUKAT (Persea americana Mill) DAN RIMPANG TEMULAWAK (Curcuma xanthorrhiza Roxb) PADA TIKUS DENGAN HIPERKOLESTEROLEMIA ; AKTIVITAS ANTI-HIPERLIPIDEMIA PADA UJI IN VIVO DARI KOMBINASI EKSTRAK DAUN ALPUKAT (Persea americana Mill) DAN RIMPANG TEMULAWAK (Curcuma xanthorrhiza Roxb) PADA TIKUS DENGAN HIPERKOLESTEROLEMIA: AKTIVITAS ANTI-HIPERLIPIDEMIA PADA UJI IN VIVO DARI KOMBINASI EKSTRAK DAUN ALPUKAT (Persea americana Mill) DAN RIMPANG TEMULAWAK (Curcuma xanthorrhiza Roxb) PADA TIKUS DENGAN HIPERKOLESTEROLEMIA

Herbal and traditional medicine are two of the main types of treatment in developing countries, including Indonesia. Hyperlipidemia is a condition in which cholesterol levels in the body exceed normal limits, impacting cardiovascular disease. Avocado leaves and temulawak rhizomes have been shown to have antihyperlipidemic effects in animals. This study aimed to determine the anti-hyperlipidemic activity of avocado leaf (Persea americana Mill) and temulawak rhizome (Curcuma xanthorrhiza Roxb) combination extract in cholesterol levels of white male mice Sprague Dawley strain. The subjects of this study consisted of 20 white male mice Sprague Dawley strain (Rattus novergicus) and were divided into five groups: F1 (standard); F2 (hypercholesterolemic group); F3 (1:1 treatment group); F4 (1:2 treatment group); and F5 (2:1 treatment group). The induction was conducted for 14 days, while the treatment was carried out for seven days. All data were analyzed using the Kruskal-Wallis and Mann-Whitney tests. The combination extract of avocado and temulawak rhizome has an anti-hyperlipidemic activity. Giving a combination extract of avocado leaf and temulawak rhizome to all treatment groups significantly reduced total cholesterol levels in mice (p = 0.028). Avocado leaves and temulawak rhizomes have potential antihyperlipidemic activity derived from flavonoids. In this study, the potency of the extract efficacy can be achieved when given in combination. ; Obat herbal dan tradisional merupakan salah satu jenis pengobatan utama di negara berkembang, termasuk Indonesia. Hiperlipidemia merupakan kondisi dimana kadar kolesterol dalam tubuh melebihi batas normal yang berdampak pada penyakit kardiovaskular. Daun alpukat dan rimpang temulawak telah terbukti memiliki efek anti-hiperlipidemia pada hewan uji. Penelitian ini bertujuan untuk mengetahui aktivitas anti- hiperlipidemia kombinasi ekstrak daun alpukat (Persea americana Mill) dan rimpang temulawak (Curcuma xanthorrhiza Roxb) terhadap kadar kolesterol total tikus putih jantan ...