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Effects of acute pre-treatment with ethanolamine on isoprenalineinduced myocardial infarction in adult Wistar rats

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  • معلومة اضافية
    • بيانات النشر:
      SA Heart Journal
    • الموضوع:
      2017
    • Collection:
      Stellenbosch University: SUNJournals
    • نبذة مختصرة :
      Ethanolamine (Etn), a biogenic amine, protects isolated hearts against MI, but its effects in vivo are unknown. In this study, we investigated the effects of Etn pretreatment on isoprenaline (ISO)-induced MI in vivo. Wistar rats were treated with either Etn (10mg.kg-1, i.p.) or saline, prior to either ISO (67mg.kg-1, s.c.) or saline. Haemodynamic- and electrocardiographic parameters were recorded under anaesthesia, 24 hours post-treatment with ISO. Infarct sizes were determined by triphenyltetrazolium chloride staining. Oxidative stress plasma parameters, conjugated dienes (CD) and thio-barbituric acid reactive substances (TBARS), were measured by spectrophotometric analysis. Etn decreased ISO-induced pathological Q-waves, but had no effect on ISO-induced low-voltage electrocardiogram. In addition, Etn decreased overall mortality induced by ISO treatment. However, Etn did not prevent ISO-induced infarction or the systolic- and diastolic hypotensive effects. Etn also enhanced the ISO-induced increase in heart-to-body weight ratio, and reversed the decrease in lungs-to-body weight ratio. Neither ISO nor Etn altered CD or TBARS. These results suggest that, despite a tendency to modulate cardiac electrical activity, Etn did not prevent ISO-induced MI or myocardial dysfunction in vivo.
    • File Description:
      application/pdf
    • Relation:
      http://www.journals.ac.za/index.php/SAHJ/article/view/1673/792; http://www.journals.ac.za/index.php/SAHJ/article/view/1673
    • الرقم المعرف:
      10.24170/13-2-1673
    • الدخول الالكتروني :
      http://www.journals.ac.za/index.php/SAHJ/article/view/1673
      https://doi.org/10.24170/13-2-1673
    • Rights:
      Copyright (c) 2017 SA Heart Journal ; https://creativecommons.org/licenses/by-nc-nd/4.0
    • الرقم المعرف:
      edsbas.D77F1EFE