Study of Correlation of Placental Morphology with Morphometrical features of Fetus in High Risk Pregnancy

INTRODUCTION: The fetus, mother and placenta constitute the triad of dynamic equilibrium in reproduction. Placenta is readily evaluable and easily accessible component of triad Placental study gives information of both infant and mother. Placenta is regarded as the diary of fetus developing inutero. It helps in maintaining and promoting normal development of fetus. It connects the fetus to uterine wall thereby allowing exchange of gasses, nutrient uptake and waste elimination and via maternal blood supply. A well nourished newborn is the best evidence of adequate placental circulation. It is a vital organ for continuation of pregnancy and nutrition of fetus. It has evoked great interest among pathologist and obstetrician to understand the unique biological status of this complex organ. Any disturbances in maternal health affects placenta, leading to decreased placental perfusion and cause fetal mortality and morbidity. Disturbance in the placental function itself affect the fetal growth. Therefore the study of changes that occur in placenta and extent of lesion will help in assessment of the degree of fetal insult inutero. AIMS & OBJECTIVES: 1. To study the histomorphological features of placenta in high risk pregnancy. 2. To analysis and correlate the morphology of placenta with fetal parameters. 3. To use Histochemical staining (Periodic Acid Schiff) and Immunohistochemistry (CD34) for demonstrating features in few groups of high risk pregnancy. MATERIALS AND METHODS: The present study was conducted in Department of Pathology, Trichy SRM medical college hospital and research center, Irungalur. DURATION OF STUDY: 2017-2019, a two year prospective study. SAMPLE SIZE: 100 cases. INCLUSION CRITERIA: Placentas of singleton pregnancy in Anemia, Gestational Diabetes Mellitus, Pregnancy induced Hypertension, preterm pregnancy, Rh negative pregnancy, Intrauterine Growth Retardation, Intrauterine Death, hypothyroid and infection (Syphilis) were taken for study. EXCLUSION CRITERIA: ◈ Placenta of non-viable fetus ...