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Maternal caffeine consumption during pregnancy and offspring cord blood DNA methylation: an epigenome-wide association study meta-analysis

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اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • بيانات النشر:
      Future Medicine
    • الموضوع:
      2023
    • Collection:
      University of Exeter: Open Research Exeter (ORE)
    • نبذة مختصرة :
      This is the final version. Available on open access from Future Medicine via the DOI in this record ; Background: Prenatal caffeine exposure may influence offspring health via DNA methylation (DNAm) but no large studies have tested this. Materials & Methods: Epigenome-wide association studies and differentially methylated regions (DMRs) in cord blood (450k or EPIC Illumina arrays) were meta 51 analysed across 6 European cohorts (n = 3742), Differential methylation related to self-reported caffeine intake (mg/day) from coffee, tea, and cola was compared to assess whether caffeine is driving effects. Results: One CpG site (cg19370043, PRRX1) was associated with caffeine and another (cg14591243, STAG1) with cola intake. 12-22 DMRs were detected with limited overlap across caffeinated beverages. Conclusions: We found little evidence to support an intrauterine effect of caffeine on
    • ISSN:
      1750-1911
    • Relation:
      orcid:0000-0003-2906-4035 (Sharp, Gemma); Vol. 15 (22), pp. 1179 - 1193; http://hdl.handle.net/10871/134402; Epigenomics
    • الرقم المعرف:
      10.2217/epi-2023-0263
    • الدخول الالكتروني :
      http://hdl.handle.net/10871/134402
      https://doi.org/10.2217/epi-2023-0263
    • Rights:
      © 2023 The Authors. Open access. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/ ; https://creativecommons.org/licenses/by-nc-nd/4.0/
    • الرقم المعرف:
      edsbas.D3DA2170