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The presence of filopodia in human blastocysts is associated with the probability of clinical pregnancy with fetal heart

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اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • بيانات النشر:
      Oxford University Press (OUP)
    • الموضوع:
      2019
    • Collection:
      UNSW Sydney (The University of New South Wales): UNSWorks
    • نبذة مختصرة :
      Purpose: Is the presence of cytoplasmic strings (CS) in human blastocysts associated with the probability of clinical pregnancy with fetal heart (CPFH) after transfer. Methods: This case-control study involved 300 single blastocyst transfers. 150 of these resulted in a CPFH (cases) while 150 did not (controls). All embryos were cultured in Embryoscope+ and AI software (IVY) was used to select the blastocyst with the highest score from the cohort for transfer. An embryologist, blind to the transfer outcome, recorded the CS number, location, and duration of their activity. Results: There was a significant difference in the number of blastocysts that contained CS, with 97.3% of women’s blastocysts resulting in +CPFH containing the CS compared to 88.7% of blastocysts in women who did not have a pregnancy (p = 0.007, OR; 4.67, CI 95% 1.5–14.2). CS appeared 2.4 h earlier in embryo development in the +CPFH group compared to their negative counterparts (p = 0.007). There was a significant difference in the average number of CS/blastocyst with a higher number being present in those that achieved a clinical pregnancy (mean: 6.2, SD 2.9) compared to those that did not (mean: 4.6, SD 3.0) (p ≤ 0.0001). There was a significant increase in the number of vesicles seen traveling along the CS with more seen in the blastocysts resulting in a +CPFH (mean: 4.3 SD 2.1) compared to those in the −CPFH group (mean: 3.1, SD 2.1). Conclusion: This study has shown that the presence of cytoplasmic strings in human blastocysts is associated with the probability of clinical pregnancy with fetal heart.
    • File Description:
      application/pdf
    • Relation:
      http://purl.org/au-research/grants/nhmrc/APP1147154; http://hdl.handle.net/1959.4/unsworks_75978; https://unsworks.unsw.edu.au/bitstreams/a65ceb7a-2952-4bce-8baa-224591b17b8d/download; https://doi.org/10.1007/s10815-021-02213-1
    • الرقم المعرف:
      10.1007/s10815-021-02213-1
    • Rights:
      open access ; https://purl.org/coar/access_right/c_abf2 ; CC-BY-NC-ND ; https://creativecommons.org/licenses/by-nc-nd/4.0/ ; free_to_read
    • الرقم المعرف:
      edsbas.D3D6644