نبذة مختصرة : International audience ; Cancer is the fisrt cause of death in France. It’s necessary to understand the resistant mechanism of tumors to current therapy (radiotherapy and chemotherapy). Hadrontherapy by Carbon irradiation seems to be a good alternative. The hadrontherapy uses accelerated ions. It’s a technique particularly interesting when the tumor is isolated and located in vital organs where it’s essential to minimize the irradiation dose in healthy arrounding tissue. The ion beams (proton or carbon) have a specific advantage over photons. When they enter the tissues, ions deposit a large part of their energy at a given depth, at the "Bragg peak, beyond, the dose decreases abruptly, which completely protects the healthy structures behind the tumor. At the same dose, protons produce the same biological effects as photons but the ballistic precision of proton allows to increase the dose to treat the tumor without touching healthy tissue. Chondrosarcoma is a good candidate for Hadrontherapy because this cancer is radio and chemo-resistant tumor. However , it’s necessary to evaluate the secondary effect of this type of irradiation especially the interaction between irradiated and non irradiated cells, there is a biological imprecision due to Bystander effect.
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