Contributors: Régulation de la réponse immune, infection VIH-1 et autoimmunité; Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM); Infections à Vih, Réservoirs, Pharmacologie des Antirétroviraux et Prévention de la Transmission Mère Enfant; Université Paris Descartes - Paris 5 (UPD5); Service Universitaire de Maladies Infectieuses et du Voyageur; Centre Hospitalier Gustave Dron; Régulation des Infections Rétrovirales; Institut Pasteur Paris (IP); INSERM U1018, Faculté de Médecine Paris Sud; Institut National de la Santé et de la Recherche Médicale (INSERM); Departement d'épidémiologie; Hôpital Bicêtre AP-HP, Le Kremlin-Bicêtre; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP); Laboratoire de Virologie CHU Necker; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Necker - Enfants Malades AP-HP; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP); The ANRS 147 OPTIPRIM trial was funded by ANRS (French National Agency for Research on AIDS and Viral Hepatitis) and conducted with the support of MSD, Janssen, ViiV Healthcare and Gilead. CL received a postdoctoral fellowship from ANRS. GP is an employee of INSERM (Institut National de la Santé et de la Recherche Médicale). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
نبذة مختصرة : International audience ; The strong CD8+ T-cell-mediated HIV-1-suppressive capacity found in a minority of HIV-infected patients in chronic infection is associated with spontaneous control of viremia. However, it is still unclear whether such capacities were also present earlier in the CD8+ T cells from non controller patients and then lost as a consequence of uncontrolled viral replication. We studied 50 patients with primary HIV-1-infection to determine whether strong CD8+ T-cell-mediated HIV suppression is more often observed at that time. Despite high frequencies of polyfunctional HIV-specific CD8+ T-cells and a strong CD4+ T-helper response, CD8+ T-cells from 48 patients lacked strong HIV-suppressive capacities ex vivo. This indicates that the superior HIV-suppressive capacity of CD8+ T-cells from HIV controllers is not a general characteristic of the HIV-specific CD8+ T cell response in primary HIV infection.
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