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Harmonization of Outcomes and Vision Endpoints in Vision Restoration Trials: Recommendations from the International HOVER Taskforce

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  • معلومة اضافية
    • بيانات النشر:
      ASSOC RESEARCH VISION OPHTHALMOLOGY INC
    • الموضوع:
      2020
    • Collection:
      The University of Melbourne: Digital Repository
    • نبذة مختصرة :
      Translational research in vision prosthetics, gene therapy, optogenetics, stem cell and other forms of transplantation, and sensory substitution is creating new therapeutic options for patients with neural forms of blindness. The technical challenges faced by each of these disciplines differ considerably, but they all face the same challenge of how to assess vision in patients with ultra-low vision (ULV), who will be the earliest subjects to receive new therapies. Historically, there were few tests to assess vision in ULV patients. In the 1990s, the field of visual prosthetics expanded rapidly, and this activity led to a heightened need to develop better tests to quantify end points for clinical studies. Each group tended to develop novel tests, which made it difficult to compare outcomes across groups. The common lack of validation of the tests and the variable use of controls added to the challenge of interpreting the outcomes of these clinical studies. In 2014, at the bi-annual International "Eye and the Chip" meeting of experts in the field of visual prosthetics, a group of interested leaders agreed to work cooperatively to develop the International Harmonization of Outcomes and Vision Endpoints in Vision Restoration Trials (HOVER) Taskforce. Under this banner, more than 80 specialists across seven topic areas joined an effort to formulate guidelines for performing and reporting psychophysical tests in humans who participate in clinical trials for visual restoration. This document provides the complete version of the consensus opinions from the HOVER taskforce, which, together with its rules of governance, will be posted on the website of the Henry Ford Department of Ophthalmology (www.artificialvision.org). Research groups or companies that choose to follow these guidelines are encouraged to include a specific statement to that effect in their communications to the public. The Executive Committee of the HOVER Taskforce will maintain a list of all human psychophysical research in the relevant fields of ...
    • ISSN:
      2164-2591
    • Relation:
      pii: TVST-19-1638; Ayton, L. N., Rizzo, J. F., Bailey, I. L., Colenbrander, A., Dagnelie, G., Geruschat, D. R., Hessburg, P. C., McCarthy, C. D., Petoe, M. A., Rubin, G. S. & Troyk, P. R. (2020). Harmonization of Outcomes and Vision Endpoints in Vision Restoration Trials: Recommendations from the International HOVER Taskforce. TRANSLATIONAL VISION SCIENCE & TECHNOLOGY, 9 (8), https://doi.org/10.1167/tvst.9.8.25.; http://hdl.handle.net/11343/251545
    • الدخول الالكتروني :
      http://hdl.handle.net/11343/251545
    • Rights:
      CC BY-NC-ND ; https://creativecommons.org/licenses/by-nc-nd/4.0
    • الرقم المعرف:
      edsbas.CF11C3C