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Toll-like receptor 5 agonist flagellin reduces influenza A virus replication independently of type I interferon and interleukin 22 and improves antiviral efficacy of oseltamivir

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  • معلومة اضافية
    • Contributors:
      Groupement des Hôpitaux de l'Institut Catholique de Lille (GHICL); Université catholique de Lille (UCL); Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 (CIIL); Institut Pasteur de Lille; Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire CHU Lille (CHRU Lille)-Centre National de la Recherche Scientifique (CNRS); Virpath-Grippe, de l'émergence au contrôle -- Virpath-Influenza, from emergence to control CIRI (Virpath); Centre International de Recherche en Infectiologie (CIRI); École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL); Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL); Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS); Pathologies Respiratoires : Protéolyse et Aérosolthérapie (PRPA); Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM); This work was funded by INSERM, CNRS, Institut Pasteur de Lille, University of Lille and Inserm-Transfert (CoPoC grant “Innatebiotic”).
    • بيانات النشر:
      HAL CCSD
      Elsevier Masson
    • الموضوع:
      2019
    • Collection:
      HAL Lyon 1 (University Claude Bernard Lyon 1)
    • نبذة مختصرة :
      International audience ; Influenza infections remain a burden on health care systems despite vaccination programs and marketed antiviral drugs. Immunomodulation through activation of innate sensors could represent innovative approaches to fight the flu. This study evaluated the ability of flagellin, agonist of Toll-like receptor 5 (TLR5), to control the replication of influenza A virus (IAV) in mice. First, we showed that systemic or intranasal administration of flagellin activated transcription of anti-viral genes in lung tissue. Prophylactic and therapeutic flagellin administration resulted in decreased levels of viral RNA and infectious virus in the lungs of H3N2 IAV-infected mice. The effect of the flagellin on viral replication was also observed in Ifnar-/- and Il22-/- IAV-infected mice, suggesting a mechanism independent of type I interferon and interleukin 22 signaling. In addition, a combination therapy associating the neuraminidase inhibitor oseltamivir and flagellin was more effective than standalone treatments in reducing pulmonary viral replication. Thus, this study highlights the therapeutic potential of the flagellin to control the replication of the influenza virus.
    • Relation:
      info:eu-repo/semantics/altIdentifier/pmid/31078648; inserm-02144074; https://inserm.hal.science/inserm-02144074; https://inserm.hal.science/inserm-02144074/document; https://inserm.hal.science/inserm-02144074/file/POSTPRINT.pdf; PUBMED: 31078648
    • الرقم المعرف:
      10.1016/j.antiviral.2019.05.002
    • الدخول الالكتروني :
      https://doi.org/10.1016/j.antiviral.2019.05.002
      https://inserm.hal.science/inserm-02144074
      https://inserm.hal.science/inserm-02144074/document
      https://inserm.hal.science/inserm-02144074/file/POSTPRINT.pdf
    • Rights:
      info:eu-repo/semantics/OpenAccess
    • الرقم المعرف:
      edsbas.CE85CD9C