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Seven new loci associated with age-related macular degeneration.

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  • معلومة اضافية
    • Contributors:
      2 Univ Michigan, Dept Biostat, Ctr Stat Genet, Ann Arbor, MI 48109 USA 3 Univ Pittsburgh, Childrens Hosp Pittsburgh, Sch Med,Med Ctr, Div Pediat Pulm Med Allergy & Immunol,Dept Pediat, Pittsburgh, PA USA 4 Boston Univ, Sch Med, Dept Med, Sect Biomed Genet, Boston, MA 02118 USA 5 Boston Univ, Sch Publ Hlth, Dept Med, Sect Biomed Genet, Boston, MA USA 6 Vanderbilt Univ, Med Ctr, Ctr Human Genet Res, Nashville, TN USA 7 Vanderbilt Univ, Dept Mol Physiol & Biophys, Sch Med, Nashville, TN 37232 USA 8 Tufts Med Ctr, Ophthalm Epidemiol & Genet Serv, Boston, MA USA 9 deCODE Genet, Reykjavik, Iceland 10 Johns Hopkins Univ, Sch Med, Wilmer Eye Inst, Dept Mol Biol & Genet, Baltimore, MD 21205 USA 11 Univ Paris 06, Dept Genet, Inst Vis, UMRS 968, Paris, France 12 Johns Hopkins Univ, Sch Med, Wilmer Eye Inst, Dept Neurosci, Baltimore, MD 21205 USA 13 Johns Hopkins Univ, Sch Med, Wilmer Eye Inst, Inst Genet Med, Baltimore, MD 21205 USA 14 RIKEN, CGM, Res Grp Genotyping, Lab Genotyping Dev, Yokohama, Kanagawa, Japan 15 Moorfields Eye Hosp, London, England 16 UCL, Inst Ophthalmol, London, England 17 Massachusetts Gen Hosp, Analyt & Translat Genet Unit, Boston, MA 02114 USA 18 Broad Inst Harvard & MIT, Stanley Ctr Psychiat Res, Cambridge, MA USA 19 Case Western Reserve Univ, Dept Epidemiol & Biostat, Cleveland, OH 44106 USA 20 Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands 21 Erasmus MC, Dept Ophthalmol, Rotterdam, Netherlands 22 Natl Univ Singapore, Ctr Mol Epidemiol, Singapore 117548, Singapore 23 Univ Pittsburgh, Grad Sch Publ Hlth, Dept Human Genet, Pittsburgh, PA 15261 USA 24 Univ Pittsburgh, Grad Sch Publ Hlth, Dept Biostat, Pittsburgh, PA 15261 USA 25 Univ Melbourne, Royal Victorian Eye & Ear Hosp, Ctr Eye Res Australia, East Melbourne, Vic, Australia 26 Columbia Univ, Dept Ophthalmol, New York, NY 10027 USA 27 Oregon Hlth & Sci Univ, Casey Eye Inst, Macular Degenerat Ctr, Portland, OR 97201 USA 28 Univ Calif San Diego, Dept Bioengn, La Jolla, CA 92093 USA 29 Vanderbilt Univ, Med Ctr, Vanderbilt Eye Inst, Nashville, TN USA 30 Vanderbilt Univ, Sch Med, Dept Ophthalmol & Visual Sci, Nashville, TN 37212 USA 31 Univ Edinburgh, Dept Ophthalmol, Edinburgh, Midlothian, Scotland 32 Princess Alexandra Eye Pavil, Edinburgh, Midlothian, Scotland 33 INSERM, U968, Paris, France 34 CNRS, UMR 7210, Paris, France 35 Singapore Natl Eye Ctr, Singapore Eye Res Inst, Singapore, Singapore 36 Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Ophthalmol, Singapore 117595, Singapore 37 Ctr Invest Clin 503, Ctr Hosp Natl Ophtalmol Quinze Vingts, INSERM Direct Hosp & Org Soins, Paris, France 38 Univ Manchester, Fac Med & Human Sci, Inst Human Dev, Manchester, Lancs, England 39 Cent Manchester Univ Hosp Natl Hlth Serv NHS Fdn, Manchester Acad Hlth Sci Ctr, Manchester, Lancs, England 40 Univ Michigan, Dept Ophthalmol & Visual Sci, Ann Arbor, MI 48109 USA 41 NEI, Neurobiol Neurodegenerabon & Repair Lab N NNRL, US Natl Inst Hlth, Bethesda, MD 20892 USA 42 Penn Presbyterian Med Ctr, Scheie Eye Inst, Philadelphia, PA USA 43 Univ Miami, Miller Sch Med, John P Hussman Inst Human Genom, Miami, FL 33136 USA 44 Univ Miami, Miller Sch Med, Dr John T Macdonald Fdn Dept Human Genet, Miami, FL 33136 USA 45 Johns Hopkins Univ, Sch Med, Wilmer Eye Inst, Dept Ophthalmol, Baltimore, MD 21205 USA 46 NEI, Immunopathol Sect, Immunol Lab, US Natl Inst Hlth, Bethesda, MD USA 47 Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore 117548, Singapore 48 Duke Natl Univ Singapore Grad Med Sch, Off Clin Sci, Ctr Quantitat Med, Singapore, Singapore 49 NEI, Div Epidemiol & Clin Applicat, US Natl Inst Hlth, Bethesda, MD 20892 USA 50 Hadassah Hebrew Univ Med Ctr, Dept Ophthalmol, Jerusalem, Israel 51 Univ Cambridge, Cambridge Inst Med Res, Dept Med Genet, Cambridge, England 52 Univ Pittsburgh, Sch Nursing, Dept Hlth Promot & Dev, Pittsburgh, PA 15261 USA 53 Univ Oregon, Inst Mol Biol, Eugene, OR 97403 USA 54 Univ Ioannina, Sch Med, Dept Hyg & Epidemiol, GR-45110 Ioannina, Greece 55 Massachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA 02114 USA 56 Broad Inst Harvard & MIT, Program Med & Populat Genet, Cambridge, MA USA 57 Univ Calif San Diego, Dept Ophthalmol, La Jolla, CA 92093 USA 58 Univ Calif San Diego, Shiley Eye Ctr, La Jolla, CA 92093 USA 59 Natl Univ Hosp Reykjavik, Dept Ophthalmol, Reykjavik, Iceland 60 Vis Res Fdn, Glaucoma Project, Madras, Tamil Nadu, India 61 Deutsch Forschungszentrum Gesundheit & Umwelt, Helmholtz Zentrum Manchen, Inst Genet Epidemiol, Neuherberg, Germany 62 Cleveland Clin Fdn, Cole Eye Inst, Cleveland, OH 44195 USA 63 Univ Liverpool, Dept Eye & Vis Sci, Inst Ageing & Chron Dis, Liverpool L69 3BX, Merseyside, England 64 Univ Munich, Augenklin, D-80539 Munich, Germany 65 Univ Bonn, Dept Ophthalmol, Bonn, Germany 66 Univ Calif San Diego, Inst Genom Med, La Jolla, CA 92093 USA 67 Stanford Univ, Dept Med, Sch Med, Stanford Prevent Res Ctr, Stanford, CA 94305 USA 68 Stanford Univ, Sch Med, Dept Hlth Res & Policy, Stanford, CA 94305 USA 69 Stanford Univ, Dept Stat, Sch Humanities & Sci, Stanford, CA 94305 USA 70 Kyushu Univ, Grad Sch Med Sci, Dept Ophthalmol, Fukuoka, Japan 71 Boston Univ, Sch Med, Dept Ophthalmol, Boston, MA 02118 USA 72 Boston Univ, Sch Publ Hlth, Dept Ophthalmol, Boston, MA 02118 USA 73 Boston Univ, Sch Med, Dept Biostat, Boston, MA 02118 USA 74 Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA USA 75 Ctr Etud Polymorphisme Humain CEPH, Fdn Jean Dausset, Paris, France 76 Duke Univ, Ctr Human Dis Modeling, Durham, NC USA 77 Duke Univ, Dept Cell Biol, Durham, NC USA 78 Duke Univ, Dept Pediat, Durham, NC 27706 USA 79 Univ Wurzburg, Dept Ophthalmol, D-97070 Wurzburg, Germany 80 Royal Perth Hosp, Dept Ophthalmol, Perth, WA, Australia 81 Univ Western Australia, Ctr Ophthalmol & Visual Sci, Perth, WA 6009, Australia 82 Harvard Univ, Sch Med, Dept Ophthalmol, Boston, MA USA 83 Massachusetts Eye & Ear Infirm, Boston, MA 02114 USA 84 Kyushu Univ, Grad Sch Med Sci, Dept Environm Med, Fukuoka, Japan 85 Univ Wisconsin, Sch Med, Dept Ophthalmol & Visual Sci, Madison, WI USA 86 Univ Wisconsin, Sch Publ Hlth, Dept Ophthalmol & Visual Sci, Madison, WI USA 87 Univ Miami, Miller Sch Med, Bascom Palmer Eye Inst, Miami, FL 33136 USA 88 Deutsch Forschungszentrum Gesundheit & Umwelt, Helmholtz Zentrum Munchen, Inst Human Genet, Neuherberg, Germany 89 Univ Southampton, Fac Med Clin & Expt Sci, Southampton, Hants, England 90 Tech Univ Munich, Inst Human Genet, D-80290 Munich, Germany 91 Univ Sydney, Dept Ophthalmol, Ctr Vis Res, Sydney, NSW 2006, Australia 92 Univ Sydney, Westmead Millennium Inst, Sydney, NSW 2006, Australia 93 Univ Paris 06, Dept Therapeut, Inst Vis, UMRS 968, Paris, France 94 Univ Utah, Dept Ophthalmol & Visual Sci, John A Moran Eye Ctr, Salt Lake City, UT USA 95 Univ Tokyo, Inst Med Sci, Ctr Human Genome, Lab Mol Med, Tokyo, Japan 96 RIKEN, Lab Stat Anal, Yokohama, Kanagawa, Japan 97 Weill Cornell Med Coll, Dept Ophthalmol, New York, NY USA 98 Univ Calif Los Angeles, David Geffen Sch Med, Dept Ophthalmol, Los Angeles, CA 90095 USA 99 Jules Stein Eye Inst, Los Angeles, CA 90024 USA 100 Univ Utah, Moran Ctr Translat Med, John A Moran Eye Ctr, Salt Lake City, UT USA 101 Seoul Natl Univ, Bundang Hosp, Dept Ophthalmol, Kyeounggi, South Korea 102 Louis Stokes Vet Affairs Med Ctr, Res Serv, Cleveland, OH USA 103 IGBMC, Lab Integrat Bioinformat & Genom, Illkirch Graffenstaden, France 104 Mayo Clin, Div Biomed Stat & Informat, Rochester, MN USA 105 Fdn Ophtalmol Adolphe Rothschild, Paris, France 106 Acad Sci Inst France, Paris, France 107 Brigham & Womens Hosp, Div Prevent Med, Boston, MA 02115 USA 108 Addenbrookes Hosp, Dept Ophthalmol, Cambridge, England 109 Univ Iceland, Fac Med, Reykjavik, Iceland 110 Queens Univ Belfast, Ctr Vis & Vasc Sci, Belfast, Antrim, North Ireland 111 Cincinnati Childrens Hosp Med Ctr, Div Human Genet, Cincinnati, OH USA 112 Columbia Univ, Dept Biomed Engn, New York, NY USA 113 Univ Paris Est, Hop Henri Mondor, Ctr Rech Clin Ophthalmol, Hop Intercommunal Creteil, Creteil, France 114 Univ Penn, Dept Ophthalmol & Genet, Philadelphia, PA 19104 USA 115 Univ Thessaly, Sch Med, Dept Ophthalmol, Larisa, Greece 116 Erasmus MC, Dept Internal Med, Rotterdam, Netherlands 117 Deutsch Forschungszentrum Gesundheit & Umwelt, Helmholtz Zentrum Munchen, Inst Epidemiol 1, Neuherberg, Germany 118 Univ Munich, Inst Med Informat, Munich, Germany 119 Univ Munich, Klinikum Grosshadern, D-80539 Munich, Germany 120 Univ Munich, Inst Biometry, Munich, Germany 121 Univ Munich, Inst Epidemiol, Munich, Germany 122 Univ Regensburg, Dept Epidemiol & Prevent Med, D-93053 Regensburg, Germany 123 Inst Genet & Mol Med, Med Res Council Human Genet Unit, Edinburgh, Midlothian, Scotland 124 Ctr Energie Atom, Inst Genom, Ctr Natl Genotypage, Evry, France 125 Sichuan Univ, West China Hosp, Mol Med Res Ctr, Chengdu 610064, Peoples R China 126 Sichuan Univ, West China Hosp, Dept Ophthalmol, Chengdu 610064, Peoples R China 127 Columbia Univ, Dept Pathol & Cell Biol, New York, NY USA 128 Univ Calif Los Angeles, David Geffen Sch Med, Dept Human Genet, Los Angeles, CA 90095 USA 129 Tufts Univ, Sch Med, Dept Ophthalmol, Boston, MA 02111 USA 130 Case Western Reserve Univ, Dept Genet, Cleveland, OH 44106 USA 131 Case Western Reserve Univ, Dept Ophthalmol & Visual Sci, Cleveland, OH 44106 USA 132 Case Western Reserve Univ, Ctr Clin Invest, Cleveland, OH 44106 USA 133 Boston Univ, Sch Med, Dept Neurol, Boston, MA 02118 USA 134 Boston Univ, Sch Publ Hlth, Dept Neurol, Boston, MA USA 135 Boston Univ, Sch Med, Dept Epidemiol, Boston, MA USA 136 Boston Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA USA
    • بيانات النشر:
      Nature Publishing Group
    • الموضوع:
      2013
    • Collection:
      Hirsla - Landspítali University Hospital research archive
    • نبذة مختصرة :
      Age-related macular degeneration (AMD) is a common cause of blindness in older individuals. To accelerate the understanding of AMD biology and help design new therapies, we executed a collaborative genome-wide association study, including >17,100 advanced AMD cases and >60,000 controls of European and Asian ancestry. We identified 19 loci associated at P < 5 × 10(-8). These loci show enrichment for genes involved in the regulation of complement activity, lipid metabolism, extracellular matrix remodeling and angiogenesis. Our results include seven loci with associations reaching P < 5 × 10(-8) for the first time, near the genes COL8A1-FILIP1L, IER3-DDR1, SLC16A8, TGFBR1, RAD51B, ADAMTS9 and B3GALTL. A genetic risk score combining SNP genotypes from all loci showed similar ability to distinguish cases and controls in all samples examined. Our findings provide new directions for biological, genetic and therapeutic studies of AMD. ; To access publisher's full text version of this article click on the hyperlink at the bottom of the page
    • ISSN:
      1546-1718
    • Relation:
      http://dx.doi.org/10.1038/ng.2578; http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3739472/; Nat. Genet. 2013, 45 (4):433-9, 439e1-2; http://hdl.handle.net/2336/324724; Nature genetics
    • الرقم المعرف:
      10.1038/ng.2578
    • Rights:
      Archived with thanks to Nature genetics ; Landspitali Access - LSH-aðgangur
    • الرقم المعرف:
      edsbas.CE540FA4