Utility of gonadotropin-releasing hormone agonists for fertility preservation in women receiving chemotherapy: pros and cons

Chemotherapy-induced ovarian damage:apoptosis and/or in vitro activation?The term‘‘ovarian reserve’’is typically used to refer to the pop-ulation ofprimordial follicles (PMFs) .This population is very sensitive to cytotoxic drugs, especially alkylating agents (cyclo-phosphamide, busulfan, ifosfamide). Among them, cyclophos-phamide (CPA) is the alkylating agent that causes the mostdamage to oocytes and granulosa cells. Alkylating-like plat-inum complexes (such as cisplatin, anthracyclanes [includingdoxorubicin]) should also be considered as ovo-toxic drugs. [.]