Peculiarities of clinical manifestation, body size and body build in women with polycystic ovary syndrome / ; Policistinių kiaušidžių sindromu sergančių moterų klinikinės raiškos, kūno dydžio ir sudėjimo ypatumai.

Dissertation topic: Peculiarities of clinical manifestation, body size and body build in women with polycystic ovary syndrome. The human body build varies greatly, whereas body size and composition changes reflect well a lot of inner processes of the organism, metabolic peculiarities, functioning of sex glands as well as other hormones. The aim of the work was to identify the peculiarities of clinical manifestation, body size and build in women with polycystic ovary syndrome (PCOS) and assess their interrelations. The study population included 116 women with PCOS and 81 controls. The cut-off values of hyperandrogenemia in the Lithuanian population were determined, which appeared to be lower than those in other populations, and they will help identify the PCOS accurately. The following peculiarities of reproductive health and metabolism in women with PCOS were found: the changed gonadotropins’ ratio, increased androgen level and hirsutism, higher probability of infertility, more frequent dyslipidemia, disturbed fasting glycemia, insulin resistance, obesity, metabolic syndrome. The frame size appeared to be large in women with PCOS, they had picnic somatotype, higher trunk and pelvis, shorter legs, and the lower facial part larger compared to those in healthy women. In women with PCOS the adipose tissue accumulates mostly in the areas of the upper trunk and upper arms, while the muscle mass is lower compared to healthy women. The morphological body size and composition indices holding the best predictive value in identifying PCOS were determined: relative leg length, chest, elbow and ankle width, frame index, metric index, shoulder-to-waist ratio, subscapular, biceps, triceps and suprailiac skinfolds, sum of arm skinfolds, arm-to-leg folds ratio and adipose tissue mass indices.