Medicinal plants of the Verbenaceae family active against yeast fungi: Systematic review and perspectives 2015-2022 ; Plantas medicinales de la familia Verbenaceae activas frente a hongos levaduriformes: Revisión sistemática y perspectivas 2015-2022 ; Plantas medicinais da família Verbenaceae ativadas frente a hongos levaduriformes: Revisão sistemática e perspectivas 2015-2022

Introduction: Opportunistic fungal infections have increased in recent decades, requiring the search for therapeutic alternatives, also considering the appearance of new species and the increase in resistance to antifungals. Objective: This study describes plants of the Verbenaceae family with therapeutic potential against yeast fungi. Methodology: A systematic review was carried from 2015 to 2020, using different databases, applying inclusion and exclusion criteria, also exploring recent perspectives to 2022. Results and discussion: 5 genera and 14 species with potential antifungal activity were found, highlighting the genus Lippia which showed greater activity. The essential oil of the leaves was the most studied natural product, mainly active against Candida albicans and Cryptococcus neoformans. Phytochemical analysis report mostly terpene-type metabolites such as carvacrol, thymol, linanol, and geraniol. For the determination of MIC, the in vitro technique of microdilution in broth was the most reported. Recent studies support the importance of species, including Lantana montevidensis (Spreng.) Briq., for their modulating activity of antifungal drugs. Conclusions: Five genera with potential activity were found: Aloysia, Lantana, Lippia, Stachytarpheta and Verbena; being of interest the species Lippia berlandieri Schauer and Lippia graveolens Kunth for its high activity against C. albicans and Cryptococcus neoformans. The importance of species of the Verbenaceae family for future research is recognized, which will allow the development of natural therapeutic alternatives against infections caused by yeast-like fungi. ; Introducción: Las infecciones fúngicas oportunistas han aumentado en las últimas décadas requiriéndose la búsqueda de alternativas terapéuticas, considerando además la aparición de nuevas especies y el aumento de la resistencia a los antifúngicos. Objetivo: Este estudio describe plantas de la familia Verbenaceae con potencial terapéutico frente a hongos levaduriformes. Metodología: Se realizó ...