نبذة مختصرة : Purpose To estimate risk of primary failure during the use of Densiron-68 in rhegmatogenous retinal detachment (RRD) cases with multiple superior and inferior retinal breaks as well as to detect possible confounder predictors of primary failure. Methods This is a retrospective case-control study. Data was collected for 52 eyes with hematogenous retinal detachment with multiple retinal breaks who were treated via pars plana vasectomy using Densiron-68 as a tamponed agent. Pars plana vasectomies had been performed from March 2014 to November 2019. Eyes were categorized into two groups based on retinal status in presence of Densiron-68 1 month postoperatively (PO). Group A: primary failure group ( n =18 eyes) and group B: Reattachment group ( n =34 eyes). In each group we observed patients records to identify distribution of retinal breaks (superior and inferior, inferior only), and to identify other confounding risk factors for primary failure; including, number of retinal breaks, age, sex, duration of symptoms, uveitis, RD Quadrants, macula status, giant retinal tear (GRT) or Dialysis, proliferative vitreoretinopathy (PVR) and grade of PVR, inferior retinectomy, and Hypotony. Results Group A ( n =18) included 13 eyes with superior and inferior breaks (SIRB) (72.2%), associated with 2.94±0.73 retinal breaks, 12 eyes with PVR (66.7%), and 3.39±0.92 quadrants of detachment. Group B( n =34) included 13 eyes with superior and inferior breaks (SIRB) (38.2%), associated with 2.4±0.5 retinal breaks, three eyes with PVR (8.8%), and 2.32±0.91 quadrants of detachment. The odds ratio for primary failure with SIRB was 4.2. Conclusion There are higher odds of primary failure following the use of Densiron-68 in cases with multiple retinal breaks that involve both superior and inferior retina, especially with a larger number of retinal breaks, a larger number of quadrants, and in the presence of PVR. We do not recommend using Densiron-68 for these cases.
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