نبذة مختصرة : Breast cancer is a significant cause of cancer-related deaths among women worldwide, including in Qatar. Tumors form due to mutations in genes, including those involved in splicing – the process of removing introns from messenger RNA (mRNA). Minor introns, a small fraction of introns, are linked to critical cellular functions relevant to cancer. They're processed by the minor spliceosome and genes containing minor introns play roles in DNA replication, repair, and transcription. This research aims to understand how breast cancer cells alter minor intron splicing to develop aggressive cancer traits. It focuses on U6atac, a key component of minor spliceosomes, and hypothesizes that breast cancer cells modify minor intron splicing to produce essential protein isoforms for aggressive cancer traits. The project aims to quantify and analyze the efficiency of minor introns under various doses of U6atac inhibition in breast cancer cell lines. It also seeks to understand why certain genes behave differently when ...
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