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MALDI-TOF mass spectrometric protein profiling of microvesicles produced by the NK-92 natural killer cell line ; Протеомное профилирование микровезикул клеток естественных киллеров линии NK-92 с помощью MALDI-масс-спектрометрии

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اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • Contributors:
      This work was supported by the Russian Foundation for Basic Research (Project Registration No. 19-015-00218) and was performed in the Department of Immunology and Cell Interactions, D. Ott Institute of Obstetrics, Gynecology, and Reproductology (St. Petersburg, Russia), partially within the institutional state assignment framework (R&D State Registration No. AAAA-A19-119021290116-1), using the equipment of Chemical Analysis and Materials Research Centre, St. Petersburg State University (St. Petersburg, Russia); Российский фонд фундаментальных исследований, НИИ акушерства, гинекологии и репродуктологии им. Д.О. Отта
    • بيانات النشر:
      SPb RAACI
    • الموضوع:
      2020
    • Collection:
      Medical Immunology (E-Journal) / Медицинская иммунология
    • نبذة مختصرة :
      Extracellular vesicles that are shed from the plasma membrane contain a wide range of molecules, among which are proteins, lipids, nucleic acids, and sugars. The cytotoxic proteins of natural killer cells play a key role in the implementation of their cytolytic functions. One of the important steps in understanding the distant communication of cells is the determination of the proteome of microvesicles. This study was aimed at the protein profiling of the microvesicles produced by the NK-92 natural killer cell line. 986 proteins with a variety of functions were identified in the lysate of microvesicles using the MALDI-TOF mass spectrometric analysis. With automated methods of functional analysis applied, it has been shown that the largest protein groups are hypothetical proteins, proteins with unknown functions, and domains. The most representative groups are also comprised by transcription regulators; intracellular signaling proteins; RNA translation, transcription, processing, and utilization regulators; receptors; protein processing and proteolysis regulators; amino acid metabolism enzymes, as well as transport proteins and transport regulators. Minor functional groups are represented by vitamins and mineral metabolism enzymes, membrane and microdomain-forming proteins, hormones, hemostatic regulators, regulators of sensory systems, specific mitochondrial and Golgi apparatus proteins, and extracellular signaling proteins. An intermediate position is occupied by various functional groups, including cytoskeleton and motor proteins; proteins of centrioles; ion channels and their regulators; proteins of the ubiquitin-proteasome pathway of protein degradation; lipid, steroid, and fatty acid metabolism enzymes; nucleic acid base and carbohydrate metabolism enzymes, as well as energy metabolism enzymes and other proteins involved in intermediate metabolism; proteins of the immune response and inflammation; antigens and histocompatibility proteins; cytokines and growth factors; regulators of apoptosis, autophagy, ...
    • File Description:
      application/pdf
    • Relation:
      https://www.mimmun.ru/mimmun/article/view/1976/1282; https://www.mimmun.ru/mimmun/article/downloadSuppFile/1976/5942; https://www.mimmun.ru/mimmun/article/downloadSuppFile/1976/5943; https://www.mimmun.ru/mimmun/article/downloadSuppFile/1976/5944; https://www.mimmun.ru/mimmun/article/downloadSuppFile/1976/5945; https://www.mimmun.ru/mimmun/article/downloadSuppFile/1976/5946; https://www.mimmun.ru/mimmun/article/downloadSuppFile/1976/5947; https://www.mimmun.ru/mimmun/article/downloadSuppFile/1976/5948; https://www.mimmun.ru/mimmun/article/downloadSuppFile/1976/5949; https://www.mimmun.ru/mimmun/article/downloadSuppFile/1976/5950; https://www.mimmun.ru/mimmun/article/downloadSuppFile/1976/5951; https://www.mimmun.ru/mimmun/article/downloadSuppFile/1976/5952; https://www.mimmun.ru/mimmun/article/downloadSuppFile/1976/5953; https://www.mimmun.ru/mimmun/article/downloadSuppFile/1976/5954; https://www.mimmun.ru/mimmun/article/downloadSuppFile/1976/5962; https://www.mimmun.ru/mimmun/article/downloadSuppFile/1976/6003; https://www.mimmun.ru/mimmun/article/downloadSuppFile/1976/6106; https://www.mimmun.ru/mimmun/article/downloadSuppFile/1976/6107; https://www.mimmun.ru/mimmun/article/downloadSuppFile/1976/6108; Brittoli A., Fallarini S., Zhang H., Pieters R.J., Lombardi G. “In vitro” studies on galectin-3 in human natural killer cells. 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    • الرقم المعرف:
      10.15789/1563-0625-MMS-1976
    • الدخول الالكتروني :
      https://www.mimmun.ru/mimmun/article/view/1976
      https://doi.org/10.15789/1563-0625-MMS-1976
    • Rights:
      Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access). ; Авторы, публикующие в данном журнале, соглашаются со следующим:Авторы сохраняют за собой авторские права на работу и предоставляют журналу право первой публикации работы на условиях лицензии Creative Commons Attribution License, которая позволяет другим распространять данную работу с обязательным сохранением ссылок на авторов оригинальной работы и оригинальную публикацию в этом журнале.Авторы сохраняют право заключать отдельные контрактные договорённости, касающиеся не-эксклюзивного распространения версии работы в опубликованном здесь виде (например, размещение ее в институтском хранилище, публикацию в книге), со ссылкой на ее оригинальную публикацию в этом журнале.Авторы имеют право размещать их работу в сети Интернет (например в институтском хранилище или персональном сайте) до и во время процесса рассмотрения ее данным журналом, так как это может привести к продуктивному обсуждению и большему количеству ссылок на данную работу (См. The Effect of Open Access).
    • الرقم المعرف:
      edsbas.C8B8B420