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Tenofovir disoproxil fumarate fails to prevent HIV acquisition or the establishment of a viral reservoir: two case reports

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اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • Contributors:
      Imperial College Healthcare NHS Trust- BRC Funding; University Of Oxford
    • بيانات النشر:
      Springer Verlag and Adis
    • الموضوع:
      2016
    • Collection:
      Imperial College London: Spiral
    • نبذة مختصرة :
      The use of antiretrovirals as pre-exposure prophylaxis (PrEP) is highly efficacious in HIV prevention. The World Health Organization recently recommended Truvada(®) (Gilead Sciences, Inc.) or tenofovir disoproxil fumarate (TDF) for high-risk individuals, with limited data for single-agent TDF PrEP in men who have sex with men (MSM). We report two cases of TDF PrEP failure in MSM who had received long-term TDF for hepatitis B infection and had therapeutic levels of drug immediately after HIV acquisition. Rapid antiretroviral intensification at diagnosis of acute HIV infection failed to limit immune dysfunction or prevent the establishment of a viral reservoir.
    • ISSN:
      2193-8229
    • Relation:
      Infectious Diseases and Therapy; http://hdl.handle.net/10044/1/31969; http://dx.doi.org/10.1007/s40121-015-0102-x; RDA02 79560; n/a
    • الرقم المعرف:
      10.1007/s40121-015-0102-x
    • الدخول الالكتروني :
      http://hdl.handle.net/10044/1/31969
      https://doi.org/10.1007/s40121-015-0102-x
    • Rights:
      This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/ by-nc/4.0/), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made
    • الرقم المعرف:
      edsbas.C6DB7F6E