Contributors: Baillie, JK; Semple, MG; Openshaw, PJM; Alex, B; Bach, B; Barclay, WS; Bogaert, D; Chand, M; Cooke, GS; Docherty, AB; Dunning, J; Da Silva Filipe, A; Fletcher, T; Green, CA; Harrison, EM; Hiscox, JA; Ying Wai Ho, A; Horby, PW; Ijaz, S; Khoo, S; Klenerman, P; Law, A; Lim, WS; Mentzer, AJ; Merson, L; Meynert, AM; Noursadeghi, M; Moore, SC; Palmarini, M; Paxton, WA; Pollakis, G; Price, N; Rambaut, A; Robertson, DL; Russell, CD; Sancho-Shimizu, V; Scott, JT; Sigfrid, L; Solomon, T; Sriskandan, S; Stuart, D; Summers, C; Tedder, RS; Thomson, EC; Thwaites, RS; Turtle, LCW; Zambon, M; Hardwick, H; Donohue, C; Ewins, J; Oosthuyzen, W; Griffiths, F; Norman, L; Pius, R; Drake, TM; Fairfield, CJ; Knight, S; Mclean, KA; Murphy, D; Shaw, CA; Dalton, J; Girvan, M; Saviciute, E; Roberts, S; Harrison, J; Marsh, L; Connor, M; Halpin, S; Jackson, C; Gamble, C; Leeming, G; Hendry, R; Greenhalf, W; Shaw, V; McDonald, S; Ahmed, KA; Armstrong, JA; Ashworth, M; Asiimwe, IG; Bakshi, S; Barlow, SL; Booth, L; Brennan, B; Bullock, K; Catterall, BWA; Clark, JJ; Clarke, EA; Cole, S; Cooper, L; Cox, H; Davis, C; Dincarslan, O; Dunn, C; Dyer, P; Elliott, A; Evans, A; Fisher, LWS; Foster, T; Garcia-Dorival, I
نبذة مختصرة : Objective To characterise the clinical features of children and young people admitted to hospital with laboratory confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in the UK and explore factors associated with admission to critical care, mortality, and development of multisystem inflammatory syndrome in children and adolescents temporarily related to coronavirus disease 2019 (covid-19) (MIS-C).Design Prospective observational cohort study with rapid data gathering and near real time analysis.Setting 260 hospitals in England, Wales, and Scotland between 17 January and 3 July 2020, with a minimum follow-up time of two weeks (to 17 July 2020).Participants 651 children and young people aged less than 19 years admitted to 138 hospitals and enrolled into the International Severe Acute Respiratory and emergency Infections Consortium (ISARIC) WHO Clinical Characterisation Protocol UK study with laboratory confirmed SARS-CoV-2.Main outcome measures Admission to critical care (high dependency or intensive care), in-hospital mortality, or meeting the WHO preliminary case definition for MIS-C.Results Median age was 4.6 (interquartile range 0.3-13.7) years, 35% (225/651) were under 12 months old, and 56% (367/650) were male. 57% (330/576) were white, 12% (67/576) South Asian, and 10% (56/576) black. 42% (276/651) had at least one recorded comorbidity. A systemic mucocutaneous-enteric cluster of symptoms was identified, which encompassed the symptoms for the WHO MIS-C criteria. 18% (116/632) of children were admitted to critical care. On multivariable analysis, this was associated with age under 1 month (odds ratio 3.21, 95% confidence interval 1.36 to 7.66; P=0.008), age 10-14 years (3.23, 1.55 to 6.99; P=0.002), and black ethnicity (2.82, 1.41 to 5.57; P=0.003). Six (1%) of 627 patients died in hospital, all of whom had profound comorbidity. 11% (52/456) met the WHO MIS-C criteria, with the first patient developing symptoms in mid-March. Children meeting MIS-C criteria were older (median age ...
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