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Early detection of neurodegeneration in brain ischemia by manganese-enhanced MRI

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  • معلومة اضافية
    • بيانات النشر:
      //www.ieeexplore.ieee.org/xpl/conhome.jsp?punumber=1000269
      United States
    • الموضوع:
      2008
    • Collection:
      University of Hong Kong: HKU Scholars Hub
    • نبذة مختصرة :
      This study aims to employ in vivo manganese-enhanced MRI (MEMRI) to detect neurodegenerative changes in two models of brain ischemia, photothrombotic cortical injury (PCI) and transient middle cerebral artery occlusion (MCAO) in rodents. After systemic Mn 2+ injection to both ischemic models, a close pattern of Tl-weighted hyperintensity was observed throughout different brain regions in comparison to the distribution of GFAP, MnSOD and GS immunoreactivities, whereby conventional MRI could hardly detect such. In addition, the infarct volumes in the posterior parts of the brain had significantly reduced after Mn 2+ injection to the MCAO model. It is suggested that exogenous Mn 2+ injection may provide enhanced MEMRI detection of oxidative stress and gliosis early after brain ischemia. Manganese may also mediate infarctions at remote brain regions in transient focal cerebral ischemia before delayed secondary damage takes place. © 2008 IEEE. ; published_or_final_version ; The 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBS) 2008, Vancouver, BC., 20-25 August 2008. in Proceedings of the 30th EMBS, 2008, p. 3884-3887
    • ISSN:
      1557-170X
    • Relation:
      Proceedings of the Annual International Conference of the IEEE Engineering in Medicine & Biology Society, EMBS 2008; http://www.scopus.com/mlt/select.url?eid=2-s2.0-61849127333&selection=ref&src=s&origin=recordpage; The 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBS) 2008, Vancouver, BC., 20-25 August 2008. In Conference Proceedings, 2008, p. 3884-3887; 3887; 182869; http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1557-170X&volume=&spage=3884&epage=3887&date=2008&atitle=Early+detection+of+neurodegeneration+in+brain+ischemia+by+manganese-enhanced+MRI; eid_2-s2.0-61849127333; 3884; http://hdl.handle.net/10722/125832; 2008
    • الرقم المعرف:
      10.1109/IEMBS.2008.4650058
    • Rights:
      IEEE Engineering in Medicine and Biology Society. Conference Proceedings. Copyright © IEEE. ; This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. ; ©2008 IEEE. Personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution to servers or lists, or to reuse any copyrighted component of this work in other works must be obtained from the IEEE.
    • الرقم المعرف:
      edsbas.C390DECB