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Multidrug-resistant Mycobacterium tuberculosis strain from Equatorial Guinea detected in Spain.

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  • معلومة اضافية
    • Contributors:
      Instituto Aragonés de Ciencias de la Salud Zaragoza (IACS); Institut Pasteur de la Guadeloupe; Réseau International des Instituts Pasteur (RIIP); Hospital Universitario Miguel Servet; This work was supported by the Spanish Fondo de Investigación Sanitaria (FIS nos. 06/1624, 03/0743 and 01/3088), CIBERES, and the Instituto de Salud Carlos III-Instituto Aragonés de Ciencias de la Salud (CM06/00100).; We thank Dessi Vaneva Marinova for assistance in writing the manuscript, and Alberto Cebollada, Carmen Lafoz, Ana Picó, and Daniel Ibarz for their excellent technical assistance. We are grateful to Thierry Zozio for helping with the geographic distribution of SIT177 in the International Spoligotyping Database (SITVIT2).
    • بيانات النشر:
      HAL CCSD
      Centers for Disease Control and Prevention
    • الموضوع:
      2009
    • Collection:
      Archive ouverte HAL (Hyper Article en Ligne, CCSD - Centre pour la Communication Scientifique Directe)
    • نبذة مختصرة :
      International audience ; This investigation focused on a specific Multidrug-Resistant (MDR) Mycobacterium tuberculosis strain from Equatorial Guinea that had been imported into Spain. Ten MDR isolates from as many patients from Equatorial Guinea were detected in Spain during 2000 through 2008. All the 10 isolates exhibited an identical genotypic pattern belonging to the Latin-American and Mediterranean (LAM) genotypic lineage of M. tuberculosis designated SIT177-LAM 9. Evidence of clonality was found for all the 10 isolates by different molecular epidemiology methods and mutations involved in drug resistance. The analysis of the RDRio deletion confirmed that the strain belonged to the major RDRio sublineage of the Latin-American and Mediterranean (LAM) genotypic lineage of M. tuberculosis which has disseminated globally.
    • Relation:
      info:eu-repo/semantics/altIdentifier/pmid/19891888; pasteur-00511967; https://hal-riip.archives-ouvertes.fr/pasteur-00511967; https://hal-riip.archives-ouvertes.fr/pasteur-00511967/document; https://hal-riip.archives-ouvertes.fr/pasteur-00511967/file/MDRTB_EID2009.pdf; PUBMED: 19891888; PUBMEDCENTRAL: PMC2857231
    • الرقم المعرف:
      10.3201/eid1511.090449
    • Rights:
      info:eu-repo/semantics/OpenAccess
    • الرقم المعرف:
      edsbas.C2850983