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Reactive oxygen-derived free radicals are key to the endothelial dysfunction of diabetes.

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اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • بيانات النشر:
      //www.wiley.com/bw/journal.asp?ref=1753-0393
    • الموضوع:
      2009
    • Collection:
      University of Hong Kong: HKU Scholars Hub
    • نبذة مختصرة :
      Vascular complications are an important pathological issue in diabetes that lead to the further functional deterioration of several organs. The balance between endothelium-dependent relaxing factors and endothelium-dependent contracting factors (EDCFs) is crucial in controlling local vascular tone and function under normal conditions. Diabetic endothelial dysfunction is characterized by reduced endothelium-dependent relaxations and/or enhanced endothelium-dependent contractions. Elevated levels of oxygen-derived free radicals are the initial source of endothelial dysfunction in diabetes. Oxygen-derived free radicals not only reduce nitric oxide bioavailability, but also facilitate the production and/or action of EDCFs. Thus, the endothelial balance tips towards vasoconstrictor responses over the course of diabetes. © 2009 Ruijin Hospital, Shanghai Jiaotong University School of Medicine and Blackwell Publishing Asia Pty Ltd. ; postprint
    • ISSN:
      1753-0407
    • Relation:
      Journal of diabetes; Journal Of Diabetes, 2009, v. 1 n. 3, p. 151-162; 8383569; 162; 181248; WOS:000208415100011; http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1753-0393&volume=1&issue=3&spage=151&epage=162&date=2009&atitle=Reactive+oxygen-derived+free+radicals+are+key+to+the+endothelial+dysfunction+of+diabetes; eid_2-s2.0-77956386834; 151; http://hdl.handle.net/10722/128492
    • الرقم المعرف:
      10.1111/j.1753-0407.2009.00030.x
    • الدخول الالكتروني :
      https://doi.org/10.1111/j.1753-0407.2009.00030.x
      http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1753-0393&volume=1&issue=3&spage=151&epage=162&date=2009&atitle=Reactive+oxygen-derived+free+radicals+are+key+to+the+endothelial+dysfunction+of+diabetes
      http://hdl.handle.net/10722/128492
    • Rights:
      This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. ; The definitive version is available at www3.interscience.wiley.com
    • الرقم المعرف:
      edsbas.C20F17F8