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Spatio-temporal variation of malaria hotspots in Central Senegal, 2008–2012

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  • معلومة اضافية
    • Contributors:
      Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale (SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD); Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM); École des Hautes Études en Santé Publique EHESP (EHESP); Vecteurs - Infections tropicales et méditerranéennes (VITROME); Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut de Recherche Biomédicale des Armées Brétigny-sur-Orge (IRBA); Campus International UCAD-IRD Dakar, Sénégal; Institut de Recherche en Santé, de Surveillance Épidémiologique et de Formation Dakar, Sénégal (IRESSEF); Unité de recherche clinique Paris Nord Val de Seine Paris (URC PNVS); AP-HP - Hôpital Bichat - Claude Bernard Paris; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP); Université des Sciences, des Techniques et des Technologies de Bamako (USTTB); Ministère de la Santé Burkina Faso; Centre d'épidémiologie et de santé publique des armées Marseille (CESPA); Service de Santé des Armées; Assistance Publique - Hôpitaux de Marseille (APHM); Hôpital Européen Fondation Ambroise Paré - Marseille; Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP); Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU); Biostatistique et technologies de l'information et de la communication (BioSTIC) - Hôpital de la Timone - APHM (BiosTIC ); Assistance Publique - Hôpitaux de Marseille (APHM)-Hôpital de la Timone CHU - APHM (TIMONE)
    • بيانات النشر:
      HAL CCSD
      BioMed Central
    • الموضوع:
      2020
    • Collection:
      Aix-Marseille Université: HAL
    • نبذة مختصرة :
      International audience ; Background: In malaria endemic areas, identifying spatio-temporal hotspots is becoming an important element of innovative control strategies targeting transmission bottlenecks. The aim of this work was to describe the spatio-temporal variation of malaria hotspots in central Senegal and to identify the meteorological, environmental, and preventive factors that influence this variation. Methods: This study analysed the weekly incidence of malaria cases recorded from 2008 to 2012 in 575 villages of central Senegal (total population approximately 500,000) as part of a trial of seasonal malaria chemoprevention (SMC). Data on weekly rainfall and annual vegetation types were obtained for each village through remote sensing. The time series of weekly malaria incidence for the entire study area was divided into periods of high and low transmission using change-point analysis. Malaria hotspots were detected during each transmission period with the SaTScan method. The effects of rainfall, vegetation type, and SMC intervention on the spatio-temporal variation of malaria hotspots were assessed using a General Additive Mixed Model. Results: The malaria incidence for the entire area varied between 0 and 115.34 cases/100,000 person weeks during the study period. During high transmission periods, the cumulative malaria incidence rate varied between 7.53 and 38.1 cases/100,000 person-weeks, and the number of hotspot villages varied between 62 and 147. During low transmission periods, the cumulative malaria incidence rate varied between 0.83 and 2.73 cases/100,000 person-weeks, and the number of hotspot villages varied between 10 and 43. Villages with SMC were less likely to be hotspots (OR = 0.48, IC95%: 0.33-0.68). The association between rainfall and hotspot status was non-linear and depended on both vegetation type and amount of rainfall. The association between village location in the study area and hotspot status was also shown. Conclusion: In our study, malaria hotspots varied over space and time ...
    • Relation:
      info:eu-repo/semantics/altIdentifier/pmid/32552759; inserm-02969228; https://inserm.hal.science/inserm-02969228; https://inserm.hal.science/inserm-02969228/document; https://inserm.hal.science/inserm-02969228/file/s12879-020-05145-w.pdf; IRD: fdi:010079123; PUBMED: 32552759; PUBMEDCENTRAL: PMC7301493
    • الرقم المعرف:
      10.1186/s12879-020-05145-w
    • Rights:
      info:eu-repo/semantics/OpenAccess
    • الرقم المعرف:
      edsbas.C14FA53B