Pro- and anti-inflammatory cytokines are significantly decreased at acute time points following IR.

Parotid tissue was dissected at days 2, 7, 14, and 30 following IR, and whole protein lysates were isolated and analyzed by cytokine array. A) TNF-α, B) IL-1β, C) IL-23, D) IL-1α, E) IL-27, F) IL-4, G) IL-17, H) TIMP-1, I) IL-2, J) IL-6, K) IL-12, L) IFN-γ, M) IL-10 analyzed by cytokine array. Data analyzed by one-way ANOVA with Tukey’s post-hoc test and represented as mean ± SEM. Treatment groups with the same letter are not statistically different from each other.