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Additional file 1 of PCDHGB7 hypermethylation-based Cervical cancer Methylation (CerMe) detection for the triage of high-risk human papillomavirus-positive women: a prospective cohort study

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  • معلومة اضافية
    • الموضوع:
      2024
    • Collection:
      Smithsonian Institution: Figshare
    • نبذة مختصرة :
      Additional file 1: Fig. S1. The clinical characteristics of the included women. (A) Histogram showing the age distribution of the included women. (B) Pie chart showing the percentage of patients diagnosed by colposcopy biopsy. (C) Bar chart showing the CerMe values’ distribution of the included women. Fig. S2. The specificity, sensitivity, and accuracy of cytology and CerMe detection in the training set. Fig. S3. The performance of cytology testing and CerMe detection stratified by age. (A) Pie chart showing the percentage of hrHPV-positive women aged 30-40 and >40 years. (B) The performance of cytology testing and CerMe detection in hrHPV-positive women aged 30-40 years. (C) The performance of cytology testing and CerMe detection in hrHPV-positive women aged >40 years. Fig. S4. CerMe detection as a triage protocol for hrHPV-positive women. (A) Flow of protocol used for other 12 hrHPV type-positive women. (B) Flow of protocol used for HPV 16/18 type-positive women. Fig. S5. The cytological characteristics of the included women. (A) Pie chart showing the percentage of patients diagnosed by cytology. (B) CerMe values of NLIM, ASC-US, LSIL, ASC-H, HSIL, and cancer cytology cases. Fig. S6. CerMe stratification combined with cytology (MeCy) provides reference for colposcopic pathology. (A) Heatmap of stratified CerMe combined Cytology (MeCy) showed the criteria of clustering MeCy negative, MeCy weakly positive, MeCy moderately positive, and MeCy strongly positive. Percentages on the 4 × 6 combinations showed the incidence of CIN2+. (B) Outlier analysis for 11 cases with strongly positive MeCy but negative colposcopy (normal or CIN1). Re-colposcopy, pathological results of a second colposcopy biopsy. NA, unavailable. Table S1. Clinical characteristics of all included women. Table S2. Diagnostic performance of hrHPV-positive women triaged by CerMe detection and Cytology testing. Table S3. Diagnostic performance of hrHPV-positive women aged 30-40 or >40 years. Table S4. Triage of other 12 hrHPV-positive or HPV ...
    • Relation:
      https://figshare.com/articles/journal_contribution/Additional_file_1_of_PCDHGB7_hypermethylation-based_Cervical_cancer_Methylation_CerMe_detection_for_the_triage_of_high-risk_human_papillomavirus-positive_women_a_prospective_cohort_study/25150657
    • الرقم المعرف:
      10.6084/m9.figshare.25150657.v1
    • Rights:
      CC BY + CC0
    • الرقم المعرف:
      edsbas.BE6FFFFE