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Questions on viral population biology to complete dengue puzzle

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اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • Contributors:
      Centre d'Etude sur le Polymorphisme des Micro-Organismes, UMR CNRS-IRD 9926 (CEPM); Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD France-Sud ); Ecologie des Systèmes Vectoriels; Institut Pasteur Paris
    • بيانات النشر:
      HAL CCSD
      Elsevier
    • الموضوع:
      2003
    • Collection:
      Archive ouverte HAL (Hyper Article en Ligne, CCSD - Centre pour la Communication Scientifique Directe)
    • نبذة مختصرة :
      International audience ; The mechanisms driving the current evolution of dengue remain unclear. We argue that disregarding the population biology of viruses has been a limiting factor, and present a hypothetical framework based on viral population biology. This allows us to pinpoint three flaws that need to be addressed: (1) a large underestimation of the viral polymorphism within populations; (2) a disregard of viral loci other than that encoding the antigenic envelope; and (3) the neglect of host-driven selection, especially that of vector-driven selection.
    • Relation:
      info:eu-repo/semantics/altIdentifier/pmid/13678856; pasteur-01713414; https://hal-pasteur.archives-ouvertes.fr/pasteur-01713414; https://hal-pasteur.archives-ouvertes.fr/pasteur-01713414/document; https://hal-pasteur.archives-ouvertes.fr/pasteur-01713414/file/Questions%20on%20viral%20population.pdf; PUBMED: 13678856
    • الرقم المعرف:
      10.1016/S0966-842X(03)00206-3
    • Rights:
      info:eu-repo/semantics/OpenAccess
    • الرقم المعرف:
      edsbas.BD12F9E7