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Relationships between intensity, duration, cumulative dose, and timing of smoking with age at menopause: A pooled analysis of individual data from 17 observational studies

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اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • Contributors:
      Department of Medicine
    • الموضوع:
      2022
    • Collection:
      University of Massachusetts, Medical School: eScholarship@UMMS
    • نبذة مختصرة :
      Full author list omitted for brevity. For the full list of authors, see article. ; BACKGROUND: Cigarette smoking is associated with earlier menopause, but the impact of being a former smoker and any dose-response relationships on the degree of smoking and age at menopause have been less clear. If the toxic impact of cigarette smoking on ovarian function is irreversible, we hypothesized that even former smokers might experience earlier menopause, and variations in intensity, duration, cumulative dose, and age at start/quit of smoking might have varying impacts on the risk of experiencing earlier menopause. METHODS AND FINDINGS: A total of 207,231 and 27,580 postmenopausal women were included in the cross-sectional and prospective analyses, respectively. They were from 17 studies in 7 countries (Australia, Denmark, France, Japan, Sweden, United Kingdom, United States) that contributed data to the International collaboration for a Life course Approach to reproductive health and Chronic disease Events (InterLACE). Information on smoking status, cigarettes smoked per day (intensity), smoking duration, pack-years (cumulative dose), age started, and years since quitting smoking was collected at baseline. We used multinomial logistic regression models to estimate multivariable relative risk ratios (RRRs) and 95% confidence intervals (CIs) for the associations between each smoking measure and categorised age at menopause ( < 40 (premature), 40-44 (early), 45-49, 50-51 (reference), and > /=52 years). The association with current and former smokers was analysed separately. Sensitivity analyses and two-step meta-analyses were also conducted to test the results. The Bayesian information criterion (BIC) was used to compare the fit of the models of smoking measures. Overall, 1.9% and 7.3% of women experienced premature and early menopause, respectively. Compared with never smokers, current smokers had around twice the risk of experiencing premature (RRR 2.05; 95% CI 1.73-2.44) (p < 0.001) and early menopause (1.80; ...
    • Relation:
      Link to Article in PubMed; PLoS Med. 2018 Nov 27;15(11):e1002704. doi:10.1371/journal.pmed.1002704. eCollection 2018 Nov. Link to article on publisher's site; 1549-1277 (Linking); http://hdl.handle.net/20.500.14038/40877; https://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=4692&context=oapubs&unstamped=1; https://escholarship.umassmed.edu/oapubs/3680; oapubs/3680
    • الرقم المعرف:
      10.1371/journal.pmed.1002704
    • الدخول الالكتروني :
      https://doi.org/10.1371/journal.pmed.1002704
      https://doi.org/20.500.14038/40877
      https://hdl.handle.net/20.500.14038/40877
      https://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=4692&context=oapubs&unstamped=1
      https://escholarship.umassmed.edu/oapubs/3680
    • Rights:
      Copyright: © 2018 Zhu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. ; http://creativecommons.org/licenses/by/4.0/
    • الرقم المعرف:
      edsbas.BC733263