نبذة مختصرة : Congenital nevi develop before birth and sometimes cover large areas of the body. They are presumed to arise from the acquisition of a gene mutation in an embryonic melanocyte that becomes trapped in the dermis during development. Mice bearing the Cdk4R24C::Tyr-NRASQ61K transgenes develop congenital nevus-like lesions by post-natal day 10, from melanocytes escaping the confines of hair follicles. We interbred these mice with the collaborative cross (CC), a resource that enables identification of modifier genes for complex diseases (those where multiple genes are involved). We examined variation in nevus cell density in 66 CC strains and mapped a large-effect quantitative trait locus (QTL) controlling nevus cell density to murine chromosome 9. The best candidate for a gene that exacerbates congenital nevus development in the context of an NRAS mutation is Cdon, a positive regulator of sonic hedgehog (Shh) that is expressed mainly in keratinocytes. ; Full Text
Relation: Pigment Cell & Melanoma Research; Chitsazan, A; Ferguson, B; Ram, R; Mukhopadhyay, P; Handoko, HY; Gabrielli, B; Soyer, PH; Morahan, G; Walker, GJ, A mutation in the Cdon gene potentiates congenital nevus development mediated by NRAS(Q61K), Pigment Cell & Melanoma Research, 2016, 29 (4), pp. 459-464; http://hdl.handle.net/10072/409330
Rights: © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. This is the peer reviewed version of the following article: Chitsazan, A; Ferguson, B; Ram, R; Mukhopadhyay, P; Handoko, HY; Gabrielli, B; Soyer, PH; Morahan, G; Walker, GJ, A mutation in the Cdon gene potentiates congenital nevus development mediated by NRAS(Q61K), Pigment Cell & Melanoma Research, 2016, 29 (4), pp. 459-464, which has been published in final form at https://doi.org/10.1111/pcmr.12487. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited. ; open access
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