Contributors: Laboratoire des Interactions Virus-Hôtes Cayenne, Guyane Française; Institut Pasteur de la Guyane; Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP); Centre National de Référence pour les Arbovirus - Laboratoire de Virologie Cayenne, Guyane française (CNR - laboratoire associé); Laboratoire de Paléontologie-Paléobiologie-Phylogénie (UMR CNRS 5554); Université Montpellier 2 - Sciences et Techniques (UM2)-Centre National de la Recherche Scientifique (CNRS); Association Kwata - Etude et protection de la nature Guyane; Biologie des Organismes et Ecosystèmes Aquatiques (BOREA); Université de Caen Normandie (UNICAEN); Normandie Université (NU)-Normandie Université (NU)-Muséum national d'Histoire naturelle (MNHN)-Institut de Recherche pour le Développement (IRD)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université des Antilles (UA); ONF - Direction régionale de la Guyane Cayenne; Office national des forêts (ONF); This study was supported by Fonds Européen de Développement Régional (FEDER) and assistance from Région Guyane and Direction Régionale pour la Recherche et la Technologie. This study benefited from European Commission Grant REGPOT-CT-2011-285837-STRonGer in the frame of FP7 and an Investissement d’Avenir Grant managed by Agence Nationale de la Recherche (Centre d’Etude de la Biodiversité Amazonienne CEBA; ANR-10-LABX-25-01).; This study was conducted within the Virus-Reservoirs-Urbanisation-Surveillance de l#x0027; Emergence en Amérique du Sud (ViRUSES) program. F.C. acknowledges the technical expertise of Michel Gillioz at the Natural History Museum of Geneva, who curated our specimens with care.; ANR-10-LABX-0025,CEBA,CEnter of the study of Biodiversity in Amazonia(2010); European Project: 285837,EC:FP7:REGPOT,FP7-REGPOT-2011-1,STRONGER(2011); European Project: ERDF/FEDER,ViRUSES
نبذة مختصرة : International audience ; A molecular screening of wild-caught rodents was conducted in French Guiana, South America to identify hosts of the hantavirus Maripa described in 2008 in a hantavirus pulmonary syndrome (HPS) case. Over a 9-year period, 418 echimyids and murids were captured. Viral RNA was detected in two sigmodontine rodents, Oligoryzomys fulvescens and Zygodontomys brevicauda, trapped close to the house of a second HPS case that occurred in 2009 and an O. fulvescens close to the fourth HPS case identified in 2013. Sequences from the rodents had 96% and 97% nucleotide identity (fragment of S and M segments, respectively) with the sequence of the first human HPS case. Phylogenetic reconstruc-tions based on the complete sequence of the S segment show that Maripa virus is closely related to Rio Mamore hantavirus. Using environmental descriptors of trapping sites, including vegetation, landscape units, rain, and human disturbance, a maximal entropy-based species distribution model allowed for identification of areas of higher predicted occurrence of the two rodents, where emergence risks of Maripa virus are expected to be higher. Hantaviruses (Bunyaviridae) are distributed worldwide.
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