Group VIII Metal Carbonyl Cluster-Boronic Acid Conjugates: Cytotoxicity and Mode of Action Studies

A set of metal carbonyl cluster-boronic acid conjugates of the group VIII metals (Fe, Ru, and Os) were synthesized and their antiproliferative effects measured against two breast cancer cell lines (MCF-7 and MDA-MB-231) and a noncancerous breast epithelial (MCF-10A) cell line. The cytotoxicity followed the order Ru > Os > Fe for the MDA-MB-231 cells, although the latter two exhibited similar cytotoxicity against MCF-7 and MCF-10A cells. The osmium species {Os 3 (CO) 10 (μ-H)­[μ-SC 6 H 4 - p -B­(OH) 2 ]} ( 2 ) could be chemically oxidized to its hydroxy analogue [Os 3 (CO) 10 (μ-H)­(μ-SC 6 H 4 -p -OH)] ( 2-OH ), which showed comparable cytotoxicity. Mode of action studies pointed to an apoptotic pathway for cell death.