Association Between Monocyte-to-High-Density Lipoprotein Ratio and Prediabetes: A Cross-Sectional Study in Chinese Population

Cairong Ruan,1– 4 Yuchen Li,1– 4 Zijing Ran,2– 4 Guodong Liu,2– 4 Weihao Li,2– 4 Xinyu Zhang,2– 4 Shanshan Shao,2– 4 Yuan Li1– 4 1Department of Endocrinology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, People’s Republic of China; 2Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, People’s Republic of China; 3Shandong Key Laboratory of Endocrinology and Lipid Metabolism, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, People’s Republic of China; 4Shandong Institute of Endocrine and Metabolic Diseases, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, People’s Republic of ChinaCorrespondence: Shanshan Shao, Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, 250021, People’s Republic of China, Tel +86-531-68776375, Fax +86-531-87068707, Email shaoshanshan11@126.com Yuan Li, Department of Endocrinology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, 250021, People’s Republic of China, Tel +86-531-68776375, Fax +86-531-87068707, Email liyuan@sdfmu.edu.cnBackground: The monocyte-to-high-density lipoprotein cholesterol (MHR) ratio has been linked to metabolic disorders. However, there is limited research on the predisposition to MHR and prediabetes. Hence, we conducted a study to investigate the relationship between MHR and the prevalence of prediabetes.Methods: In total, 85,293 participants were included in our cross-sectional observational study. Multivariable regression analysis, subgroup analyses, and interaction testing were used to determine the relationship between MHR and prediabetes. To explore the non-linear association of MHR with prediabetes risk, generalized additive model (GAM) and smoothing ...