The proteomics behind clinical and temporal changes in Parkinson's Disease: a literature review ; La proteómica detrás de los cambios clínicos y temporales en la Enfermedad de Parkinson: una revisión sistemática ; A proteômica por trás das alterações clínicas e temporais na Doença de Parkinson: uma revisão de literatura

Parkinson's disease (PD) is characterized by the dopaminergic neuron's progressive neurodegeneration, which is chronic and results in movement and behavioral disorders. There are still many gaps in the PD etiology and pathogenesis. Thus, aiming to strengthen the evidence that serves as a tool for diagnostic aid and future treatments, this systematic review aims to relate and analyze studies on the PARK proteomics, that is, the class of expressed park proteins that are associated with pathogenesis, PD clinical changes, and temporal effects. 261 papers were selected for eligibility analysis based on their title and abstract, resulting in 56 papers, with a full reading, included in this study. The observed result leads to the understanding of gene expression for a class of proteins that participate in cellular metabolic pathways associated with the PD etiology. Genetic studies applied to proteomics investigated disease-linked loci of PARK genes and their gene expression to relate the cellular pathways that contribute to PD. It was observed that PARK proteins corroborate the PD pathogenesis, highlighting the hypothesis of change in perception over time. Therefore, exploratory, and systematic studies can guide future investigations and strengthen clinically applied evidence. ; La enfermedad de Parkinson (EP) se caracteriza por la neurodegeneración progresiva de las neuronas dopaminérgicas, que es crónica y produce trastornos del movimiento y del comportamiento. Todavía existen muchas lagunas en la etiología y patogenia de la EP. Así, con el objetivo de fortalecer la evidencia que sirva como herramienta de ayuda diagnóstica y tratamientos futuros, esta revisión sistemática tiene como objetivo relacionar y analizar estudios sobre la proteómica de PARKS, es decir, la clase de proteínas park expresadas que se asocian con patogénesis, cambios clínicos. y efectos temporales de la EP. Se seleccionaron 261 artículos para el análisis de elegibilidad en función de su título y resumen, lo que resultó en 56 artículos, con ...