Item request has been placed! ×
Item request cannot be made. ×
loading  Processing Request

Development of barley and yeast β-glucan aerogels for drug delivery by supercritical fluids

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • بيانات النشر:
      Elsevier
    • الموضوع:
      2017
    • Collection:
      Universidade of Minho: RepositóriUM
    • نبذة مختصرة :
      Polysaccharide aerogels are a good alternative as carriers for drug delivery, since they allow high loading of the active compounds in matrices that are non-toxic, biocompatible and from a renewable feedstock. In this work, barley and yeast β-glucans aerogels were produced by gelation in aqueous solution, followed by solvent exchange and drying with supercritical CO2. First, viscoelastic properties and melting profile of the hydrogels were determined. Then, the obtained aerogels were analyzed regarding morphology, mechanical properties and behavior in physiological fluid. Both in the hydrogels and in the aerogels, big differences were observed between barley and yeast β-glucans due to their different chain structure and gelation behavior. Finally, impregnation of acetylsalicylic acid was performed at the same time as the drying of the alcogels with supercritical CO2. The release profile of the drug in PBS was analyzed in order to determine the mechanism governing the release from the β-glucan matrix. ; Authors acknowledge Ministerio de Economía y Competitividad (MINECO) through project CTQ2013-44143-R and project PIP 063/ 147181 from Fundación General of the University of Valladolid for fi- nancial support. M. Salgado thanks to Ministerio de Educación, Ciencia y Deporte (MECD) for her FPU and mobility grants. S. Rodríguez-Rojo acknowledges to MINECO and UVa for her Juan de la Cierva fellowship (JCI-2012-14992). The research leading to these results has received funding from the European Union Seventh Framework Programme (FP7/2007-2013) under grant agreement number REGPOT-CT2012- 316331-POLARIS and from the project “Novel smart and biomimetic materials for innovative regenerative medicine approaches” RL1 − ABMR − NORTE-01-0124-FEDER-000016) co-financed by North Portugal Regional Operational Programme (ON.2–O Novo Norte), under the National Strategic Reference Framework (NSRF), through the European Regional Development Fund (ERDF). ; info:eu-repo/semantics/publishedVersion
    • File Description:
      application/pdf
    • ISSN:
      2212-9820
    • Relation:
      info:eu-repo/grantAgreement/EC/FP7/316331/EU; https://www.sciencedirect.com/science/article/pii/S2212982017303190?via%3Dihub; Salgado M., Santos F., Rodríguez-Rojo S., Reis R. L., Duarte A. R. C., Cocero M. J. Development of barley and yeast β-glucan aerogels for drug delivery by supercritical fluids, Journal of CO₂ Utilization, Vol. 22, Issue -, pp. 262–269, doi:10.1016/j.jcou.2017.10.006, 2017; http://hdl.handle.net/1822/51426
    • الرقم المعرف:
      10.1016/j.jcou.2017.10.006
    • الدخول الالكتروني :
      http://hdl.handle.net/1822/51426
      https://doi.org/10.1016/j.jcou.2017.10.006
    • Rights:
      info:eu-repo/semantics/openAccess
    • الرقم المعرف:
      edsbas.B99E80F3