Contributors: Department of Anatomy, Histology, Forensic Medicine and Orthopedic Roma (DAHFMO); Institut Pasteur, Fondation Cenci Bolognetti - Istituto Pasteur Italia, Fondazione Cenci Bolognetti; Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Università degli Studi di Roma "La Sapienza" = Sapienza University Rome (UNIROMA); School of Medicine, Institute of Histology and Embryology; Università cattolica del Sacro Cuore = Catholic University of the Sacred Heart Roma (Unicatt); Thérapie des maladies du muscle strié; Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS); School of Sport and Exercise Sciences; Liverpool John Moores University (LJMU); Institute for Biomedical Research into Human Movement; Health Manchester Metropolitan University; Dept. Experimental Pathology; Alma Mater Studiorum Università di Bologna = University of Bologna (UNIBO); Division of Clinical Physiology; University of Nottingham, UK (UON); Center for Life Nano Science@Sapienza; Istituto Italiano di Tecnologia (IIT); Work in the authors’ laboratories has been supported by Seventh Framework Programme-Myoage and partly by MIUR, Fondazione Roma, Fondation Thierry Latran, AFM (to AM, VM and GBB) and AFLD (to VM).
نبذة مختصرة : International audience ; Although adult skeletal muscle is composed of fully differentiated fibers, it retains the capacity to regenerate in response to injury and to modify its contractile and metabolic properties in response to changing demands. The major role in the growth, remodeling and regeneration is played by satellite cells, a quiescent population of myogenic precursor cells that reside between the basal lamina and plasmalemma and that are rapidly activated in response to appropriate stimuli. However, in pathologic conditions or during aging, the complete regenerative program can be precluded by fibrotic tissue formation and resulting in functional impairment of the skeletal muscle. Our study, along with other studies, demonstrated that although the regenerative program can also be impaired by the limited proliferative capacity of satellite cells, this limit is not reached during normal aging, and it is more likely that the restricted muscle repair program in aging is presumably due to missing signals that usually render the damaged muscle a permissive environment for regenerative activity.
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