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Association of LIfestyle for BRAin health risk score (LIBRA) and genetic susceptibility with incident dementia and cognitive decline

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  • معلومة اضافية
    • Contributors:
      Bordeaux population health (BPH); Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM); Rush University Medical Center Chicago; CIC Bordeaux; Université Bordeaux Segalen - Bordeaux 2-Institut National de la Santé et de la Recherche Médicale (INSERM); Institut des Maladies Neurodégénératives Bordeaux (IMN); Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS); Institut des Neurosciences de Montpellier (INM); Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM); Université de Montpellier (UM); Sanofi; Fondation pour la Recherche Médicale; Mutuelle Générale de l'Education Nationale; Conseil Régional Aquitaine; Conseil régional de Bourgogne-Franche-Comté; Fondation de France; Fondation Plan Alzheimer; Caisse nationale de solidarité pour l'autonomie; Roche Diagnostics; ANR-06-PNRA-0005,COGINUT,COGINUT : Cognition, anti-oxydants, acides gras: approche interdisciplinaire du rôle de la nutrition dans le vieillissement du cerveau(2006); ANR-07-LVIE-0003,COGICARE,Histoire naturelle du déclin cognitif et du besoin de soins chez le sujet âgé(2007)
    • بيانات النشر:
      HAL CCSD
      Alzheimer's Association / Wiley
    • الموضوع:
      2024
    • Collection:
      Université de Montpellier: HAL
    • نبذة مختصرة :
      International audience ; INTRODUCTION: Evaluating whether genetic susceptibility modifies the impact of lifestyle-related factors on dementia is critical for prevention.METHODS: We studied 5170 participants from a French cohort of older persons free of dementia at baseline and followed for up to 17 years. The LIfestyle for BRAin health risk score (LIBRA) including 12 modifiable factors was constructed at baseline (higher score indicating greater risk) and was related to both subsequent cognitive decline and dementia incidence, according to genetic susceptibility to dementia (reflected by the apolipoprotein E [APOE] ε4 allele and a genetic risk score [GRS]).RESULTS: The LIBRA was associated with higher dementia incidence, with no significant effect modification by genetics (hazard ratio for one point score = 1.09 [95% confidence interval, 1.05; 1.13]) in APOE ε4 non-carriers and = 1.15 [1.08; 1.22] in carriers; P = 0.15 for interaction). Similar findings were obtained with the GRS and with cognitive decline. DISCUSSION: Lifestyle-based prevention may be effective whatever the genetic susceptibility to dementia.
    • Relation:
      info:eu-repo/semantics/altIdentifier/pmid/38775256; hal-04627251; https://hal.science/hal-04627251; https://hal.science/hal-04627251/document; https://hal.science/hal-04627251/file/BPH_AlzheimersDement_2024_Neuffer.pdf; PUBMED: 38775256; PUBMEDCENTRAL: PMC11180843
    • الرقم المعرف:
      10.1002/alz.13801
    • Rights:
      http://creativecommons.org/licenses/by-nc/ ; info:eu-repo/semantics/OpenAccess
    • الرقم المعرف:
      edsbas.B8EFECC8