Contributors: Galderisi, S.; Rucci, P.; Kirkpatrick, B.; Mucci, A.; Gibertoni, D.; Rocca, P.; Rossi, A.; Bertolino, A.; Strauss, G. P.; Aguglia, E.; Bellomo, A.; Murri, M. B.; Carpiniello, B.; Comparelli, A.; De Berardis, D.; Dell'Osso, L.; DI FABIO, Fabio; Gelao, B.; Marchesi, C.; Monteleone, P.; Montemagni, C.; Orsenigo, G.; Pacitti, F.; Roncone, R.; Santonastaso, P.; Vignapiano, A.; Vita, A.; Zeppegno, P.; Maj, M.; Aiello, C.; Molle, D.; Nicita, A.; Patriarca, S.; Pietrafesa, D.; Longo, L.; Falsetti, A.; Barone, M.; Galluzzo, A.; Barlati, S.; Deste, G.; Pinna, F.; Primavera, D.; Sanna, L.; Signorelli, M.; Minutolo, G.; Cannavo, D.; Corbo, M.; Baroni, G.; Montemitro, C.; Altamura, M.; La Montagna, M.; Carnevale, R.; Amore, M.; Calcagno, P.; Bugliani, M.; Parnanzone, S.; Rossi, R.; Serrone, D.; Giusti, L.; Malavolta, M.; Salza, A.; Caldiroli, A.; Mandolini, G.; De Carlo, V.; de Bartolomeis, A.; Gramaglia, C.; Marangon, D.; Prosperini, P.; Pierluigi, E.; Meneguzzo, P.; Giannunzio, V.; Tonna, M.; Ossola, P.; Gerra, M. L.; Gesi, C.; Cremone, I. M.; Carpita, B.; Brugnoli, R.; Del Casale, A.; Corigliano, V.; Biondi, M.; Zocconali, M.; Buzzanca, A.; Corrivetti, G.; Pinto, G.; Diasco, F.; Fagiolini, A.; Goracci, A.; Bolognesi, S.; Niolu, C.; Di Lorenzo, G.; Ribolsi, M.; Mancini, I.; Brasso, C.; Bozzatello, P.; Bucci, Paola; Cuomo, Alessandro Ottavio; Siracusano, Alberto
نبذة مختصرة : IMPORTANCE Enhanced understanding of factors associated with symptomatic and functional recovery is instrumental to designing personalized treatment plans for people with schizophrenia. To date, this is the first study using network analysis to investigate the associations among cognitive, psychopathologic, and psychosocial variables in a large sample of community-dwelling individuals with schizophrenia. OBJECTIVE To assess the interplay among psychopathologic variables, cognitive dysfunctions, functional capacity, personal resources, perceived stigma, and real-life functioning in individuals with schizophrenia, using a data-driven approach. DESIGN, SETTING, AND PARTICIPANTS This multicenter, cross-sectional study involved 26 university psychiatricclinicsand/or mental health departments. Atotal of 921 community-dwelling individuals with a DSM-IV diagnosis of schizophrenia who were stabilized on antipsychotictreatment were recruited from those consecutively presenting to the outpatient units of the sites between March 1, 2012, and September 30, 2013. Statistical analysis was conducted between July 1 and September 30, 2017. MAIN OUTCOMES AND MEASURES Measures covered psychopathologic variables, neurocognition, social cognition, functional capacity, real-life functioning, resilience, perceived stigma, incentives, and service engagement. RESULTS Of 740 patients (221 women and 519 men; mean [SD] age, 40.0 [10.9] years) with complete data on the 27 study measures, 163 (22.0%) were remitted (with a score of mild or better on 8 core symptoms). The network analysis showed that functional capacity and everyday life skills were the most central and highly interconnected nodes in the network. Psychopathologic variables split in2domains, with positive symptoms being one of the most peripheral and least connected nodes. Functional capacity bridged cognition with everyday life skills; the everyday life skills node was connected todisorganization and expressive deficits. Interpersonal relationships and work skills were ...
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