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Systemic lupus erythematosus with juvenile onset: current status of the problem (literature review) ; Системная красная волчанка с ювенильным началом: современное состояние проблемы (обзор литературы)

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  • معلومة اضافية
    • Contributors:
      The article was prepared within the framework of the basic scientific topic №1021051302580-4.; Статья подготовлена в рамках фундаментальной научной темы №1021051302580-4.
    • بيانات النشر:
      IMA-PRESS, LLC
    • الموضوع:
      2024
    • Collection:
      Modern Rheumatology Journal / Современная ревматология
    • نبذة مختصرة :
      Patients with juvenile-onset systemic lupus erythematosus (jSLE) account for up to 25% of all SLE patients. The main difference between jSLE and SLE in adults is the greater role of genetic factors in the pathogenesis, higher activity, earlier development of complications and the need for more aggressive immunosuppressive therapy, which allows us to consider the onset of the disease in childhood as a special phenotype of SLE. The relevance of the study of jSLE arises from the variability of clinical manifestations and the unpredictability of the course, the difficulty of early diagnosis, the rapid development of organ damage and the unfavorable life prognosis.The article presents the most important modern data on the diagnosis, classification, features of the clinical picture and treatment approaches of jSLE from a practical point of view. ; Больные системной красной волчанкой (СКВ) с ювенильным началом (юСКВ) составляют до 25% всех больных СКВ. Главное отличие юСКВ от СКВ у взрослых состоит в большей роли в ее возникновении генетических факторов, более высокой активности, раннем развитии осложнений и потребности в более агрессивной иммуносупрессивной терапии, что позволяет расценивать дебют заболевания в детском возрасте как особый фенотип СКВ. Актуальность изучения юСКВ определяется вариабельностью ее клинических проявлений и непредсказуемостью течения, трудностью ранней диагностики, быстрым развитием органных повреждений и неблагоприятным жизненным прогнозом.В статье представлены наиболее значимые с практической точки зрения современные данные о диагностике, классификации, особенностях клинической картины и подходах к терапии юСКВ.
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    • Relation:
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    • الرقم المعرف:
      10.14412/1996-7012-2024-2-95-102
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    • الرقم المعرف:
      edsbas.B8D68CBB