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Association of corneal nerve fiber measures with cognitive function in dementia

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  • معلومة اضافية
    • Contributors:
      School of Medicine (Host institution)
    • بيانات النشر:
      U.K., John Wiley & Sons
    • الموضوع:
      2019
    • Collection:
      University of Western Sydney (UWS): Research Direct
    • نبذة مختصرة :
      Objectives: Corneal confocal microscopy (CCM) is a noninvasive ophthalmic technique that identifies corneal nerve degeneration in a range of peripheral neuropathies and in patients with multiple sclerosis, Parkinson's disease, and amyotrophic lateral sclerosis. We sought to determine whether there is any association of corneal nerve fiber measures with cognitive function and functional independence in patients with MCI and dementia. Methods: In this study, 76 nondiabetic participants with MCI (n = 30), dementia (n = 26), and healthy age-matched controls (n = 20) underwent assessment of cognitive and physical function and CCM. Results: There was a progressive reduction in corneal nerve fiber density (CNFD), branch density (CNBD), and fiber length (CNFL) (P < 0.0001) in patients with MCI and dementia compared to healthy controls. Adjusted for confounders, all three corneal nerve fiber measures were significantly associated with cognitive function (P < 0.05) and functional independence (P < 0.01) in MCI and dementia. The area under the ROC curve to distinguish MCI with CNFD, CNBD, and CNFL was 69.1%, 73.2%, and 73.0% and for dementia it was 84.8%, 84.2%, and 86.2%, respectively. Interpretation: CCM demonstrates corneal nerve fiber loss, which is associated with a decline in cognitive function and functional independence in patients with MCI and dementia.
    • File Description:
      print
    • Relation:
      Annals of Clinical and Translational Neurology--2328-9503 Vol. 6 Issue. 4 pp: 689-697
    • الرقم المعرف:
      10.1002/acn3.746
    • الدخول الالكتروني :
      https://doi.org/10.1002/acn3.746
      http://handle.westernsydney.edu.au:8081/1959.7/uws:51691
    • Rights:
      © 2019 The Authors. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
    • الرقم المعرف:
      edsbas.B86C4513