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Infant neurodevelopment and behavior in Guadeloupe after lead exposure and Zika maternal infection during pregnancy

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اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • Contributors:
      Institut de recherche en santé, environnement et travail (Irset); Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique EHESP (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes (Biosit : Biologie - Santé - Innovation Technologique); École des Hautes Études en Santé Publique EHESP (EHESP); Centre de recherche du CHU de Québec-Université Laval (CRCHUQ); CHU de Québec–Université Laval; Université Laval Québec (ULaval)-Université Laval Québec (ULaval); Département des sciences en santé environnementale (DEESSE); Centre d'Investigation Clinique Antilles-Guyane (CIC - Antilles Guyane); Université des Antilles et de la Guyane (UAG)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pointe-à-Pitre / Abymes Guadeloupe -CHU de Fort de France-Centre Hospitalier Andrée Rosemon Cayenne, Guyane Française; CHU Pointe-à-Pitre / Abymes Guadeloupe; This research was funded by: the Agence Française pour la Biodiversité (AFB/2018/172) as part of the national ECOPHYTO PLAN II, within the framework of the French National Research Programme for Environmental and Occupational Health (PNR-EST), coordinated by ANSES; the Regional Health Agency of Guadeloupe (ARS/VSS/2018), and the European Union’s Horizon 2020 Research and Innovation Programme through the ZIKAlliance project (under Grant Agreement No. 734548). The ZIKA_DFA_FE/BB studies were supported by the French Ministry of Health (Soutien Exceptionnel à la Recherche et à l′Innovation).; Collaboration internationale; European Project: 734548,ZIKAlliance(2016)
    • بيانات النشر:
      HAL CCSD
      Elsevier
    • الموضوع:
      2023
    • Collection:
      Université des Antilles (UAG): HAL
    • نبذة مختصرة :
      International audience ; BACKGROUND: Prenatal lead exposure is known to have neurotoxic effects on the developing fetus, while some viral infections may have a tropism for the central nervous system. Our objective was to study whether the effects of prenatal lead exposure on infant development and behaviors at 18 months of age are modified by the occurrence of a maternal infection to Zika virus (ZIKV) during pregnancy. METHODS: During the ZIKV epidemic in Guadeloupe in 2016 a cohort of pregnant women was set up. Blood samples (pregnancy, childbirth and cord) (n = 297) enabled us to measure blood lead levels aimed to determine prenatal lead exposure and the likelihood of maternal infection during pregnancy (ZIKV status + vs -). The 18 months "Ages and Stages Questionnaire" (ASQ) was used to generate scores for global development, fine and gross motor skills, communication, problem solving, and personal-social skills. The questions from a longitudinal cohort study conducted in Canada (Québec) were used to generate hyperactivity, opposition, inattention and physical aggression scores. Associations were tested by multivariate linear regressions. RESULTS: Prenatal lead exposure was associated with delays in neurodevelopment at 18 months, reflected by lower scores in ASQ totals, and in the fine motor and problem-solving domains. Some of these associations appeared to be sex-specific, observed almost exclusively in boys (ASQ total, fine motor and personal-social scores). Prenatal lead exposure was not associated with behavioral scores. ZIKV infection during pregnancy was associated with a lower fine motor ASQ score, and higher scores for hyperactivity, opposition and physical aggression. Significant interaction between prenatal lead exposure and ZIKV status was observed with a lower personal-social score in ZIKV (-) only, and for hyperactivity and inattention scores, though some of these interactions (ASQ personal-social score, inattention score) were no longer significant when children with microcephaly were excluded ...
    • Relation:
      info:eu-repo/semantics/altIdentifier/pmid/36402195; info:eu-repo/grantAgreement//734548/EU/A global alliance for Zika virus control and prevention/ZIKAlliance; PUBMED: 36402195
    • الرقم المعرف:
      10.1016/j.neuro.2022.11.007
    • الدخول الالكتروني :
      https://hal.science/hal-03889698
      https://hal.science/hal-03889698v1/document
      https://hal.science/hal-03889698v1/file/Kadawathagedara%20et%20al.%20-%202022%20-%20Infant%20Neurodevelopment%20and%20Behavior%20in%20Guadeloupe.pdf
      https://doi.org/10.1016/j.neuro.2022.11.007
    • Rights:
      info:eu-repo/semantics/OpenAccess
    • الرقم المعرف:
      edsbas.B75634C2