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New photocrosslinked 3D foamed scaffolds based on GelMA copolymers: potential application in bone tissue engineering

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  • معلومة اضافية
    • Contributors:
      MDPI
    • بيانات النشر:
      MDPI
    • الموضوع:
      2023
    • Collection:
      Universidad Complutense de Madrid (UCM): E-Prints Complutense
    • الموضوع:
      54
    • نبذة مختصرة :
      2023 Descuentos MDPI ; The production of customized polymeric hydrogels in the form of 3D scaffolds with application in bone tissue engineering is currently a topic of great interest. Based on gelatin methacryloyl (GelMa) as one of the most popular used biomaterials, GelMa with two different methacryloylation degrees (DM) was obtained, to achieve crosslinked polymer networks by photoinitiated radical polymerization. In this work, we present the obtention of new 3D foamed scaffolds based on ternary copolymers of GelMa with vinylpyrrolidone (VP) and 2-hydroxyethylmethacrylate (HEMA). All biopolymers obtained in this work were characterized by infrared spectroscopy (FTIR) and thermogravimetric analysis (TGA), whose results confirm the presence of all copolymers in the crosslinked biomaterial. In addition, scanning electron microscopy (SEM) pictures were obtained verifying the presence of the porosity created by freeze-drying process. In addition, the variation in its swelling degree and its enzymatic degradation in vitro was analyzed as a function of the different copolymers obtained. This has allowed us to observe good control of the variation in these properties described above in a simple way by varying the composition of the different comonomers used. Finally, with these concepts in mind, biopolymers obtained were tested through assessment of several biological parameters such as cell viability and differentiation with MC3T3-E1 pre-osteoblastic cell line. Results obtained show that these biopolymers maintain good results in terms of cell viability and differentiation, along with tunable properties in terms of hydrophilic character, mechanical properties and enzymatic degradation. © 2023 by the authors. ; Instituto de Salud Carlos III (España) ; European Research Council ; European Commission ; Ministerio de Ciencia e Innovación (España) ; Depto. de Química en Ciencias Farmacéuticas ; Fac. de Farmacia ; TRUE ; pub ; Pagado por el autor
    • File Description:
      application/pdf
    • ISSN:
      2310-2861
    • Relation:
      info:eu-repo/grantAgreement/MINECO//PID2021-124926NB-I00; info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 (ISCIII)/PI20%2F01384/ES/DISEÑO DE UN NUEVO BIOMATERIAL CON POTENCIAL OSTEOINDUCTOR PARA EL TRATAMIENTO DE DEFECTOS OSEOS/; 694160; https://hdl.handle.net/20.500.14352/103690; Pablos, J.L.; Jiménez-Holguín, J.; Salcedo, S.S.; Salinas, A.J.; Corrales, T.; Vallet-Regí, M. New Photocrosslinked 3D Foamed Scaffolds Based on GelMA Copolymers: Potential Application in Bone Tissue Engineering. Gels 2023, 9, 403. https://doi.org/10.3390/gels9050403; https://doi.org/10.3390/gels9050403
    • الرقم المعرف:
      10.3390/gels9050403
    • Rights:
      Attribution 4.0 International ; http://creativecommons.org/licenses/by/4.0/ ; open access
    • الرقم المعرف:
      edsbas.B7216043