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A new sulfonyl glucoside eugenol and antioxidant phenolic compounds from Lannea Acida and Lannea Welwitschii

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  • معلومة اضافية
    • Contributors:
      Université Félix Houphouët-Boigny (UFHB); Institut de Chimie Moléculaire de Reims - UMR 7312 (ICMR); Université de Reims Champagne-Ardenne (URCA)-Institut de Chimie - CNRS Chimie (INC-CNRS)-SFR CAP Santé (Champagne-Ardenne Picardie Santé); Université de Reims Champagne-Ardenne (URCA)-Université de Reims Champagne-Ardenne (URCA)-Centre National de la Recherche Scientifique (CNRS)-SFR Condorcet; Université de Reims Champagne-Ardenne (URCA)-Centre National de la Recherche Scientifique (CNRS)-Université de Reims Champagne-Ardenne (URCA)-Centre National de la Recherche Scientifique (CNRS)
    • بيانات النشر:
      HAL CCSD
      Society for Advance Healthcare Research
    • الموضوع:
      2022
    • Collection:
      Université de Reims Champagne-Ardenne: Archives Ouvertes (HAL)
    • نبذة مختصرة :
      International audience ; A new unusual eugenyl-O-β-D-(6'-sulphonylglucopyranoside) and 17 polyphenols have been isolated from the leaves of Lannea acida and Lannea welwitschii. The structures of the compounds were established using NMR and HR-ESI-MS spectroscopic analysis. Six compounds namely myricetin 3-O-β-D-arabinofuranoside 1, myricetin-3-O-β-D-glucuronic acid 2, myricetin-3-O-β-D-xylofuranoside 3, myricetin 4, mearnsetin 5, myricetin-3-O-β-Dgalactopyranoside 6, were isolated from L. welwitschii. Twelve others including the new eugenyl-O-β-D-(6'-sulphonylglucoside) 7, myricetin-3-(6''-galloylgalactoside) 8, quercetin-3-O-β-D-glucuronic acid 9, quercetin-3-O-β-D-glucopyranoside 10, (-)-epigallocatechin-3gallate 11, (-)-epicatechin-3-gallate 12, myricetin-3-O-α-L-rhamnopyranoside 13, myricetin-3-O-β-D-glucopyranoside 14, 3,4,5-trigalloylquinic acid 15 and (-)-epigallocatechin 16, quercetin-3-(6''-galloylglucopyranoside) 17 and (-)-epicatechin 18 were obtained from Lannea acida. The antioxidant activity of 2, 4, 5, 10, 11, 12, 13, 14, 17 and 18 were evaluated by the DPPH (2, 2'-diphenyl-1-picrylhydrazyl) free radical-scavenging and CUPRAC method. Others due to their inadequate quantities were not evaluated. Compound 18 (IC50 7.8 ± 0.1 µg / mL), 4 (IC50 18.6 ± 4.5 µg / mL), 2 (IC50 20.0 ± 0.1µg / mL) and 13 (IC50 20.0 ± 0.9 µg / mL) showed better activity than the controls, ascorbic acid (IC50 23.17 ± 2.02) and quercetin (IC50 31.67 ± 2.88 µg / mL). This is the first report of the isolation of eugenyl-O-β-D-(6'sulphonylglucopyranoside. The seventeen (17) known compounds were reported for the first time in L. welwitschii and L. acida. Future studies would involve the anti-inflammatory and anticancer activities of these compounds.
    • Relation:
      hal-03509812; https://hal.univ-reims.fr/hal-03509812; https://hal.univ-reims.fr/hal-03509812/document; https://hal.univ-reims.fr/hal-03509812/file/Manuscript_Koffi%20Kouam%C3%A9_EJBPS_2021_HAL.pdf
    • الدخول الالكتروني :
      https://hal.univ-reims.fr/hal-03509812
      https://hal.univ-reims.fr/hal-03509812/document
      https://hal.univ-reims.fr/hal-03509812/file/Manuscript_Koffi%20Kouam%C3%A9_EJBPS_2021_HAL.pdf
    • Rights:
      info:eu-repo/semantics/OpenAccess
    • الرقم المعرف:
      edsbas.B54B2386