نبذة مختصرة : Protein phosphorylation is a major regulatory mechanism that controls many players in several basic cellular processes, indeed it is estimated that 30% of the proteome is subjected to phosphorylation. The phosphorylated state of a protein is a balance between the action of protein kinases and protein phosphatases that act on the same substrate. The phosphorylated state of a protein can change its fate in terms of subcellular localization, activity or stability. In this review we will focus on some examples of proteins that are regulated by phosphorylation and involved in the control of cell cycle progression, mitosis and cytokinesis in Saccharomyces cerevisiae.
No Comments.