نبذة مختصرة : Scheme electron microscopy. From CFU-S (colony forming units-spleen) stem cells arise CFU-GM (colony forming unit-granulocyte/monocyte) stem cells. The latter divide by mitoses and differentiate via promyeloblasts and myeloblasts into myelocytes (the last proliferative stage). The neutrophilic myelocyte (10-15 μm) contains a large nucleus (nucleoli disappear) and well developed organelles, a distinct Golgi area and specific or secondary granules. The primary ('non-specific' or azurophilic) granules (0.3-0.4 μm) are electron-grey (1) and contain among others acid phosphatase and arylsulfatase. The secondary (specific) electron-dense granules (2) contain lysosome and phagocytin.
No Comments.