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Accuracy of HBeAg to identify pregnant women at risk of transmitting hepatitis B virus to their neonates: a systematic review and meta-analysis

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اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • Contributors:
      Epidémiologie des Maladies Emergentes - Emerging Diseases Epidemiology; Pasteur-Cnam Risques infectieux et émergents (PACRI); Institut Pasteur Paris (IP)-Conservatoire National des Arts et Métiers CNAM (CNAM)-Institut Pasteur Paris (IP)-Conservatoire National des Arts et Métiers CNAM (CNAM); Organisation Mondiale de la Santé / World Health Organization Office Genève, Suisse (OMS / WHO); Tokyo Medical and Dental University Japan (TMDU); Peking University Beijing; University of Calgary; Université d'Angers (UA); Centre Hospitalier Universitaire Yalgado Ouédraogo Ouagadougou, Burkina Faso (CHUYO); Centre Hospitalier Régional Universitaire Montpellier (CHRU Montpellier); Pathogenesis and Control of Chronic and Emerging Infections (PCCEI); Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Université des Antilles (UA)-Etablissement français du don du sang Montpellier; Global Influenza Programme; Oregon Health and Science University Portland (OHSU); Centers for Disease Control and Prevention Kenya; We thank WHO for funding this work, the Guidelines Development Group for their critical review of this work, and Yvan Hutin for coordinating the development of the WHO guideline
    • بيانات النشر:
      HAL CCSD
      Elsevier Science
      The Lancet Pub. Group, 2001-
    • الموضوع:
      2021
    • Collection:
      Institut Pasteur: HAL
    • نبذة مختصرة :
      International audience ; Background: Prevention of mother-to-child transmission (MTCT) of hepatitis B virus (HBV) involves neonatal immunoprophylaxis, with a birth dose of hepatitis B vaccine and immune globulin, and provision of peripartum antiviral prophylaxis in highly viraemic women. However, access to assays to quantify HBV DNA levels remains inadequate in resource-poor settings. This study was commissioned by WHO and aimed to identify the HBV DNA threshold for MTCT, to assess the sensitivity and specificity of hepatitis B e antigen (HBeAg) testing to identify pregnant women with HBV DNA levels above this threshold, and to predict MTCT of HBV infection on the basis of HBeAg testing.Methods: For this systematic review and meta-analysis, we searched the PubMed, EMBASE, Scopus, CENTRAL, CNKI, and Wanfang databases for studies of pregnant women with chronic HBV infection without concurrent antiviral therapy, published between Jan 1, 2000, and April 3, 2019. Studies were eligible for inclusion if MTCT in mother-child pairs could be stratified by different levels of maternal HBV DNA during pregnancy, if maternal HBeAg status could be stratified by HBV DNA level, and if the MTCT status of infants could be stratified by maternal HBeAg status during pregnancy. Studies that selected pregnant women on the basis of HBeAg serostatus or HBV DNA levels were excluded. Aggregate data were extracted from eligible studies by use of a pre-piloted form; study authors were contacted to clarify any uncertainties about potential duplication or if crucial information was missing. To pool sensitivities and specificities of maternal HBeAg to identify highly viraemic women and to predict MTCT events, we used the DerSimonian-Laird bivariate random effects model. This study is registered with PROSPERO, CRD42019138227.Findings: Of 9007 articles identified, 67 articles (comprising 66 studies) met the inclusion criteria. The risk of MTCT despite infant immunoprophylaxis was negligible (0·04%, 95% CI 0·00-0·25) below a maternal HBV DNA ...
    • Relation:
      info:eu-repo/semantics/altIdentifier/pmid/32805201; hal-03493664; https://hal.science/hal-03493664; https://hal.science/hal-03493664/document; https://hal.science/hal-03493664/file/S1473309920305934.pdf; PII: S1473-3099(20)30593-4; PUBMED: 32805201
    • الرقم المعرف:
      10.1016/S1473-3099(20)30593-4
    • الدخول الالكتروني :
      https://hal.science/hal-03493664
      https://hal.science/hal-03493664/document
      https://hal.science/hal-03493664/file/S1473309920305934.pdf
      https://doi.org/10.1016/S1473-3099(20)30593-4
    • Rights:
      http://creativecommons.org/licenses/by-nc/ ; info:eu-repo/semantics/OpenAccess
    • الرقم المعرف:
      edsbas.B168F10E