Rod and Rod-Driven Function in Achromatopsia and

PURPOSE. To evaluate rod photoreceptor and postreceptor ret-inal function in pediatric patients with achromatopsia (ACHR) and blue cone monochromatism (BCM) using contemporary electroretinographic (ERG) procedures. METHODS. Fifteen patients (age range, 1–20 years) with ACHR and six patients (age range, 4–22 years) with BCM were stud-ied. ERG responses to full-field stimuli were obtained in scotopic and photopic conditions. Rod photoreceptor (Srod, Rrod) and rod-driven postreceptor (log , Vmax) response pa-rameters were calculated from the a-wave and b-wave. ERG records were digitally filtered to demonstrate the oscillatory potentials (OPs); a sensitivity parameter, log SOPA1⁄2, and an amplitude parameter, SOPAmax, were used to characterize the OP response. Response parameters were compared with those of 12 healthy control subjects.