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Vitamin D : status, genetic polymorphisms, cancer risk and modulation by individual characteristics ; Vitamine D : statut, polymorphismes génétiques, risque de cancer et modulation par des facteurs individuels

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  • معلومة اضافية
    • Contributors:
      Equipe 3: EREN- Equipe de Recherche en Epidémiologie Nutritionnelle (CRESS - U1153); Université Paris 13 (UP13)-Institut National de la Recherche Agronomique (INRA)-Conservatoire National des Arts et Métiers CNAM (CNAM)-Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)); Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM); Université Sorbonne Paris Cité; Serge Hercberg; Mathilde Touvier
    • بيانات النشر:
      HAL CCSD
    • الموضوع:
      2016
    • Collection:
      Institut National de la Recherche Agronomique: ProdINRA
    • نبذة مختصرة :
      Two main parts structured this PhD thesis. In the first part (descriptive work, SU.VI.MAX and NutriNet-Santé cohorts), we identified factors that influenced vitamin D status, some of which being modifiable (e.g. moderate sun exposure, physical activity, normal weight) and as such constitute interesting targets for public health policies. Using these determinants, we developed the VDIP score in order to simply identify adults at risk of vitamin d insufficiency. Finally, the study dealing with vitamin D-related knowledge showed that the primary sources of vitamin D-related information were the physicians and the media and that some confusion existed regarding the sources and the proven/unproven health effects of vitamin D.In a second part (etiological work, nested case-control study, SU.VI.MAX cohort), we showed that a higher vitamin D status (within the low-to-moderate range of plasma 25(OH)D concentrations observed in this study) may be associated with a decreased risk of breast, prostate and tobacco-related cancers. These associations were modified by individual factors such as weight status and alcohol intake (in particular breast cancer). The studied genetic polymorphisms confirmed the associations observed with vitamin D status.In a context where vitamin D arouses considerable interest, these results may contribute to a better understanding of the factors that influence vitamin D status, to a better insight of what people know and believe regarding vitamin D and to a better understanding of the role of vitamin D in the etiology of cancer. These PhD findings could eventually contribute to the optimization of public health nutritional recommendations for the improvement of vitamin D status in the population and for cancer primary prevention. ; Ce travail de thèse s’articule en deux parties. Dans une première partie (aspects descriptifs, cohortes SU.VI.MAX et NutriNet-Santé), nous avons mis en évidence différents facteurs influençant le statut en vitamine D, parmi lesquels certains sont modifiables et ...
    • Relation:
      NNT: 2016USPCD073; tel-02137432; https://theses.hal.science/tel-02137432; https://theses.hal.science/tel-02137432/document; https://theses.hal.science/tel-02137432/file/edgalilee_th_2016_deschasaux.pdf
    • الدخول الالكتروني :
      https://theses.hal.science/tel-02137432
      https://theses.hal.science/tel-02137432/document
      https://theses.hal.science/tel-02137432/file/edgalilee_th_2016_deschasaux.pdf
    • Rights:
      info:eu-repo/semantics/OpenAccess
    • الرقم المعرف:
      edsbas.ADF27F0D